A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine
Migraine headache is a widespread and complex neurobiological disorder that is characterized by unilateral headaches that are often accompanied by photophobia and phonophobia. Migraine is one of the leading chief complaints in the emergency department with negative impacts on quality of life and act...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Medical Publishing
2022-06-01
|
| Series: | Health Psychology Research |
| Online Access: | https://doi.org/10.52965/001c.35506 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823857565574889472 |
|---|---|
| author | Nazir Noor Alexis Angelette Abby Lawson Anjana Patel Ivan Urits Omar Viswanath Cyrus Yazdi Alan D. Kaye |
| author_facet | Nazir Noor Alexis Angelette Abby Lawson Anjana Patel Ivan Urits Omar Viswanath Cyrus Yazdi Alan D. Kaye |
| author_sort | Nazir Noor |
| collection | DOAJ |
| description | Migraine headache is a widespread and complex neurobiological disorder that is characterized by unilateral headaches that are often accompanied by photophobia and phonophobia. Migraine is one of the leading chief complaints in the emergency department with negative impacts on quality of life and activities of daily living. The high number of emergency presentations also results in a significant economic burden. Its risk factors include family history, genetics, sex, race, socioeconomics, the existence of comorbid conditions, and level of education. Triggers include stress, light, noise, menstruation, weather, changes in sleep pattern, hunger, dehydration, dietary factors, odors, and alcohol. The International Headache Society has defined criteria for the diagnosis of migraine with and without aura. The pathophysiology of migraine headaches is multifactorial so there are a variety of treatment approaches. The current treatment approach includes abortive medications and prophylactic medications. Abortive medications include the first-line treatment of triptans, followed by ergot alkaloids, and calcitonin gene-related peptide (CGRP) receptor antagonists along with supplemental caffeine and antiemetics. Trigeminal afferents from the trigeminal ganglion innervate most cranial tissues and many areas of the head and face. These trigeminal afferents express certain biomarkers such as calcitonin gene-related peptide (CGRP), substance P, neurokinin A, and pituitary adenylate cyclase-activating polypeptide that are important to the pain and sensory aspect of migraines. In this comprehensive review, we discuss Zavegepant, a calcitonin gene-related peptide receptor antagonist, as a new abortive medication for migraine headaches. |
| format | Article |
| id | doaj-art-5fbf99b2e321483898118b4a099bb9d5 |
| institution | Kabale University |
| issn | 2420-8124 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Health Psychology Research |
| spelling | doaj-art-5fbf99b2e321483898118b4a099bb9d52025-02-11T20:30:29ZengOpen Medical PublishingHealth Psychology Research2420-81242022-06-01102A Comprehensive Review of Zavegepant as Abortive Treatment for MigraineNazir NoorAlexis AngeletteAbby LawsonAnjana PatelIvan UritsOmar ViswanathCyrus YazdiAlan D. KayeMigraine headache is a widespread and complex neurobiological disorder that is characterized by unilateral headaches that are often accompanied by photophobia and phonophobia. Migraine is one of the leading chief complaints in the emergency department with negative impacts on quality of life and activities of daily living. The high number of emergency presentations also results in a significant economic burden. Its risk factors include family history, genetics, sex, race, socioeconomics, the existence of comorbid conditions, and level of education. Triggers include stress, light, noise, menstruation, weather, changes in sleep pattern, hunger, dehydration, dietary factors, odors, and alcohol. The International Headache Society has defined criteria for the diagnosis of migraine with and without aura. The pathophysiology of migraine headaches is multifactorial so there are a variety of treatment approaches. The current treatment approach includes abortive medications and prophylactic medications. Abortive medications include the first-line treatment of triptans, followed by ergot alkaloids, and calcitonin gene-related peptide (CGRP) receptor antagonists along with supplemental caffeine and antiemetics. Trigeminal afferents from the trigeminal ganglion innervate most cranial tissues and many areas of the head and face. These trigeminal afferents express certain biomarkers such as calcitonin gene-related peptide (CGRP), substance P, neurokinin A, and pituitary adenylate cyclase-activating polypeptide that are important to the pain and sensory aspect of migraines. In this comprehensive review, we discuss Zavegepant, a calcitonin gene-related peptide receptor antagonist, as a new abortive medication for migraine headaches.https://doi.org/10.52965/001c.35506 |
| spellingShingle | Nazir Noor Alexis Angelette Abby Lawson Anjana Patel Ivan Urits Omar Viswanath Cyrus Yazdi Alan D. Kaye A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine Health Psychology Research |
| title | A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine |
| title_full | A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine |
| title_fullStr | A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine |
| title_full_unstemmed | A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine |
| title_short | A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine |
| title_sort | comprehensive review of zavegepant as abortive treatment for migraine |
| url | https://doi.org/10.52965/001c.35506 |
| work_keys_str_mv | AT nazirnoor acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT alexisangelette acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT abbylawson acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT anjanapatel acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT ivanurits acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT omarviswanath acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT cyrusyazdi acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT alandkaye acomprehensivereviewofzavegepantasabortivetreatmentformigraine AT nazirnoor comprehensivereviewofzavegepantasabortivetreatmentformigraine AT alexisangelette comprehensivereviewofzavegepantasabortivetreatmentformigraine AT abbylawson comprehensivereviewofzavegepantasabortivetreatmentformigraine AT anjanapatel comprehensivereviewofzavegepantasabortivetreatmentformigraine AT ivanurits comprehensivereviewofzavegepantasabortivetreatmentformigraine AT omarviswanath comprehensivereviewofzavegepantasabortivetreatmentformigraine AT cyrusyazdi comprehensivereviewofzavegepantasabortivetreatmentformigraine AT alandkaye comprehensivereviewofzavegepantasabortivetreatmentformigraine |