In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study)
The present research was carried out to assess the toxic effect of oral administration of the aqueous extract of Nerium oleander leaves and flowers daily at doses of (25) mg/kg body weight for four weeks in mice. The toxicity of this plant parts was determined after two and four weeks by measuring t...
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University of Baghdad, College of Science for Women
2011-03-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2506 |
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| description | The present research was carried out to assess the toxic effect of oral administration of the aqueous extract of Nerium oleander leaves and flowers daily at doses of (25) mg/kg body weight for four weeks in mice. The toxicity of this plant parts was determined after two and four weeks by measuring the parameters of cytogenetic (mitotic index, micronucleus %), and serum levels of the hematological (RBC, Hb, WBC) and biochemical (GOT, GPT, ALT, AST) indexes in comparison with that of the control (normal saline), also clinical signs were determined. The results showed a significant decrease in mitotic index while an obvious raise was seen in micronucleus percentage in comparison with that of the control after the two periods of administration. More over significant marked changes was seen in the level of all the hematological and biochemical parameters when compared with the control. In addition to that, diarrhea with some organ lesions were also observed. |
| format | Article |
| id | doaj-art-5fbad473a8c0461b808aad0e7cfd1ef4 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-5fbad473a8c0461b808aad0e7cfd1ef42025-08-20T03:14:41ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862011-03-018110.21123/bsj.8.1.366-372In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study)Baghdad Science JournalThe present research was carried out to assess the toxic effect of oral administration of the aqueous extract of Nerium oleander leaves and flowers daily at doses of (25) mg/kg body weight for four weeks in mice. The toxicity of this plant parts was determined after two and four weeks by measuring the parameters of cytogenetic (mitotic index, micronucleus %), and serum levels of the hematological (RBC, Hb, WBC) and biochemical (GOT, GPT, ALT, AST) indexes in comparison with that of the control (normal saline), also clinical signs were determined. The results showed a significant decrease in mitotic index while an obvious raise was seen in micronucleus percentage in comparison with that of the control after the two periods of administration. More over significant marked changes was seen in the level of all the hematological and biochemical parameters when compared with the control. In addition to that, diarrhea with some organ lesions were also observed.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2506Nerium oleander, cytogenetic, hematology, biochemistry |
| spellingShingle | Baghdad Science Journal In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study) مجلة بغداد للعلوم Nerium oleander, cytogenetic, hematology, biochemistry |
| title | In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study) |
| title_full | In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study) |
| title_fullStr | In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study) |
| title_full_unstemmed | In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study) |
| title_short | In Vivo Toxicity Study of Nerium oleander's Leaves and Flowers Aqueous Extracts in Mice (Cytogenetic, Biochemical and Hematological Study) |
| title_sort | in vivo toxicity study of nerium oleander s leaves and flowers aqueous extracts in mice cytogenetic biochemical and hematological study |
| topic | Nerium oleander, cytogenetic, hematology, biochemistry |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2506 |
| work_keys_str_mv | AT baghdadsciencejournal invivotoxicitystudyofneriumoleandersleavesandflowersaqueousextractsinmicecytogeneticbiochemicalandhematologicalstudy |