Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran
Background. Human papillomavirus (HPV) is one of the most important viral agents associated with several classes of cancers in humans. The aim of this study was to investigate HPV in esophageal cancer in the East Azerbaijan province, northwest of Iran. Methods. 140 paraffin-embedded specimens of eso...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2022/1099477 |
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| author | Zahra Sadeghian Hossein Bannazadeh Baghi Vahdat Poortahmasebi Javid Sadeghi Alka Hasani Arezoo Azadi Mahin Ahangar Oskouee |
| author_facet | Zahra Sadeghian Hossein Bannazadeh Baghi Vahdat Poortahmasebi Javid Sadeghi Alka Hasani Arezoo Azadi Mahin Ahangar Oskouee |
| author_sort | Zahra Sadeghian |
| collection | DOAJ |
| description | Background. Human papillomavirus (HPV) is one of the most important viral agents associated with several classes of cancers in humans. The aim of this study was to investigate HPV in esophageal cancer in the East Azerbaijan province, northwest of Iran. Methods. 140 paraffin-embedded specimens of esophageal tissues were investigated using nested-polymerase chain reaction (nested-PCR) with primer designing for the L1 region of HPV genome. According to the pathological diagnosis, the samples were divided into two groups: 70 patients with esophageal cancer EADC (n = 35) and ESCC (n = 35) as the case group and those without tumour in esophagus tissue as a control (n = 70). Results. HPV DNA was isolated from 20 (28.57%) of the 70 paraffin-embedded tissue specimens of esophagus cancer. Of these, 6 cases (17.14%) of EADC and 14 cases (40%) of ESCC were positive. In contrast, all cases of the control group were negative for the HPV genome. Sequence analysis revealed that HPV types 16 and 18 are the most frequent ones identified in this study. Conclusion. The prevalence of HPV in esophageal cancer can vary depending on the geographical location and other factors. Based on the findings of this study, HPV infection may possibly have contributed to an increased risk of esophageal cancer in a group of patients in Tabriz. |
| format | Article |
| id | doaj-art-5fba23417d584f70929a5d0080f91f59 |
| institution | Kabale University |
| issn | 1918-1493 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-5fba23417d584f70929a5d0080f91f592025-02-03T05:44:38ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932022-01-01202210.1155/2022/1099477Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of IranZahra Sadeghian0Hossein Bannazadeh Baghi1Vahdat Poortahmasebi2Javid Sadeghi3Alka Hasani4Arezoo Azadi5Mahin Ahangar Oskouee6Department of Microbiology and VirologyDepartment of Microbiology and VirologyDepartment of Microbiology and VirologyDepartment of Microbiology and VirologyDepartment of Microbiology and VirologyDepartment of Microbiology and VirologyDepartment of Microbiology and VirologyBackground. Human papillomavirus (HPV) is one of the most important viral agents associated with several classes of cancers in humans. The aim of this study was to investigate HPV in esophageal cancer in the East Azerbaijan province, northwest of Iran. Methods. 140 paraffin-embedded specimens of esophageal tissues were investigated using nested-polymerase chain reaction (nested-PCR) with primer designing for the L1 region of HPV genome. According to the pathological diagnosis, the samples were divided into two groups: 70 patients with esophageal cancer EADC (n = 35) and ESCC (n = 35) as the case group and those without tumour in esophagus tissue as a control (n = 70). Results. HPV DNA was isolated from 20 (28.57%) of the 70 paraffin-embedded tissue specimens of esophagus cancer. Of these, 6 cases (17.14%) of EADC and 14 cases (40%) of ESCC were positive. In contrast, all cases of the control group were negative for the HPV genome. Sequence analysis revealed that HPV types 16 and 18 are the most frequent ones identified in this study. Conclusion. The prevalence of HPV in esophageal cancer can vary depending on the geographical location and other factors. Based on the findings of this study, HPV infection may possibly have contributed to an increased risk of esophageal cancer in a group of patients in Tabriz.http://dx.doi.org/10.1155/2022/1099477 |
| spellingShingle | Zahra Sadeghian Hossein Bannazadeh Baghi Vahdat Poortahmasebi Javid Sadeghi Alka Hasani Arezoo Azadi Mahin Ahangar Oskouee Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran |
| title_full | Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran |
| title_fullStr | Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran |
| title_full_unstemmed | Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran |
| title_short | Evidence of High-Risk Human Papillomavirus in Esophageal Cancer in East Azerbaijan Province, Northwest of Iran |
| title_sort | evidence of high risk human papillomavirus in esophageal cancer in east azerbaijan province northwest of iran |
| url | http://dx.doi.org/10.1155/2022/1099477 |
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