Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents
Three series of novel compounds derived from 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid bearing piperazine carboxamides, (5-(substituted phenyl)-1,3,4-oxadiazol-2-yl) and (5-(alkylthio)-1,3,4-oxadiazol-2-yl) substitutions at the 4-position were synthesized. Synthesized compounds were...
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| Format: | Article |
| Language: | English |
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Springer
2017-02-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610315000356 |
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| author | Rahul P. Jadhav Hemant N. Raundal Amar A. Patil Vivek D. Bobade |
| author_facet | Rahul P. Jadhav Hemant N. Raundal Amar A. Patil Vivek D. Bobade |
| author_sort | Rahul P. Jadhav |
| collection | DOAJ |
| description | Three series of novel compounds derived from 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid bearing piperazine carboxamides, (5-(substituted phenyl)-1,3,4-oxadiazol-2-yl) and (5-(alkylthio)-1,3,4-oxadiazol-2-yl) substitutions at the 4-position were synthesized. Synthesized compounds were characterized by 1H NMR, 13C NMR and mass spectral analysis and evaluated for their antimicrobial activities. Interestingly, most of the compounds exhibit moderate to good activities against tested Gram-positive, Gram-negative bacterial strains as well as fungal strains. |
| format | Article |
| id | doaj-art-5fac80dff63f4eadb19564155e629da8 |
| institution | Kabale University |
| issn | 1319-6103 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj-art-5fac80dff63f4eadb19564155e629da82025-08-20T03:49:04ZengSpringerJournal of Saudi Chemical Society1319-61032017-02-0121215215910.1016/j.jscs.2015.03.003Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agentsRahul P. JadhavHemant N. RaundalAmar A. PatilVivek D. BobadeThree series of novel compounds derived from 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid bearing piperazine carboxamides, (5-(substituted phenyl)-1,3,4-oxadiazol-2-yl) and (5-(alkylthio)-1,3,4-oxadiazol-2-yl) substitutions at the 4-position were synthesized. Synthesized compounds were characterized by 1H NMR, 13C NMR and mass spectral analysis and evaluated for their antimicrobial activities. Interestingly, most of the compounds exhibit moderate to good activities against tested Gram-positive, Gram-negative bacterial strains as well as fungal strains.http://www.sciencedirect.com/science/article/pii/S13196103150003561,3,4-OxadiazolePiperazineAntibacterial activityAntifungal activity |
| spellingShingle | Rahul P. Jadhav Hemant N. Raundal Amar A. Patil Vivek D. Bobade Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents Journal of Saudi Chemical Society 1,3,4-Oxadiazole Piperazine Antibacterial activity Antifungal activity |
| title | Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents |
| title_full | Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents |
| title_fullStr | Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents |
| title_full_unstemmed | Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents |
| title_short | Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents |
| title_sort | synthesis and biological evaluation of a series of 1 4 disubstituted 1 2 3 triazole derivatives as possible antimicrobial agents |
| topic | 1,3,4-Oxadiazole Piperazine Antibacterial activity Antifungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319610315000356 |
| work_keys_str_mv | AT rahulpjadhav synthesisandbiologicalevaluationofaseriesof14disubstituted123triazolederivativesaspossibleantimicrobialagents AT hemantnraundal synthesisandbiologicalevaluationofaseriesof14disubstituted123triazolederivativesaspossibleantimicrobialagents AT amarapatil synthesisandbiologicalevaluationofaseriesof14disubstituted123triazolederivativesaspossibleantimicrobialagents AT vivekdbobade synthesisandbiologicalevaluationofaseriesof14disubstituted123triazolederivativesaspossibleantimicrobialagents |