Integrated mathematical and experimental modeling uncovers enhanced EMT plasticity upon loss of the DLC1 tumor suppressor.

Integrated mathematical and experimental modeling uncovers enhanced EMT plasticity upon loss of the DLC1 tumor suppressor.

Epithelial-mesenchymal transition (EMT) plays an essential role in embryonic development, wound healing, and tumor progression. Partial EMT states have been linked to metastatic dissemination and drug resistance. Several interconnected feedback loops at the RNA and protein levels control the transit...

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Bibliographic Details
Main Authors: Sebastian Höpfl, Merih Özverin, Helena Nowack, Raluca Tamas, Andrew G Clark, Nicole Radde, Monilola A Olayioye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013076
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