Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses
Introduction: Primary breast lymphoma (PBL) is a rare non-Hodgkin lymphoma, predominantly presenting as diffuse large B-cell lymphoma (DLBCL) and primarily affecting the breast, often misdiagnosed due to its nonspecific symptoms resembling breast carcinoma. Breast implants are among...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-02-01
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| Series: | Case Reports in Oncology |
| Online Access: | https://karger.com/article/doi/10.1159/000543952 |
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| author | Ahmad Al-Bitar Amnah Zahreddin Mohammed Shwin Abdullah Barbar Alaa Dirani |
| author_facet | Ahmad Al-Bitar Amnah Zahreddin Mohammed Shwin Abdullah Barbar Alaa Dirani |
| author_sort | Ahmad Al-Bitar |
| collection | DOAJ |
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Introduction:
Primary breast lymphoma (PBL) is a rare non-Hodgkin lymphoma, predominantly presenting as diffuse large B-cell lymphoma (DLBCL) and primarily affecting the breast, often misdiagnosed due to its nonspecific symptoms resembling breast carcinoma. Breast implants are among the most frequently used medical devices for esthetic and reconstructive purposes.
Case Presentation:
We present a 24-year-old female with a growing breast mass who was diagnosed with PBL (non-Hodgkin’s DLBCL). She underwent successful R-CHOP chemotherapy, resulting in complete remission. Follow-up imaging showed no distant metastasis or significant residual disease, with silicone implants intact and no pathological uptake.
Conclusion:
PBL is a rare malignancy that primarily affects postmenopausal women, with diagnosis relying on radiologic investigations and histopathology due to its clinical and imaging similarities to breast carcinoma. Treatment is controversial and often involves rituximab-based chemotherapy, intrathecal methotrexate, and radiotherapy, with improved outcomes observed in recent years.
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| format | Article |
| id | doaj-art-5fa68cd49d7b4560990add6500367707 |
| institution | Kabale University |
| issn | 1662-6575 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj-art-5fa68cd49d7b4560990add65003677072025-08-20T03:49:41ZengKarger PublishersCase Reports in Oncology1662-65752025-02-0118127127710.1159/000543952Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast ProsthesesAhmad Al-Bitarhttps://orcid.org/0009-0009-3173-1942Amnah ZahreddinMohammed ShwinAbdullah BarbarAlaa Dirani Introduction: Primary breast lymphoma (PBL) is a rare non-Hodgkin lymphoma, predominantly presenting as diffuse large B-cell lymphoma (DLBCL) and primarily affecting the breast, often misdiagnosed due to its nonspecific symptoms resembling breast carcinoma. Breast implants are among the most frequently used medical devices for esthetic and reconstructive purposes. Case Presentation: We present a 24-year-old female with a growing breast mass who was diagnosed with PBL (non-Hodgkin’s DLBCL). She underwent successful R-CHOP chemotherapy, resulting in complete remission. Follow-up imaging showed no distant metastasis or significant residual disease, with silicone implants intact and no pathological uptake. Conclusion: PBL is a rare malignancy that primarily affects postmenopausal women, with diagnosis relying on radiologic investigations and histopathology due to its clinical and imaging similarities to breast carcinoma. Treatment is controversial and often involves rituximab-based chemotherapy, intrathecal methotrexate, and radiotherapy, with improved outcomes observed in recent years. https://karger.com/article/doi/10.1159/000543952 |
| spellingShingle | Ahmad Al-Bitar Amnah Zahreddin Mohammed Shwin Abdullah Barbar Alaa Dirani Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses Case Reports in Oncology |
| title | Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses |
| title_full | Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses |
| title_fullStr | Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses |
| title_full_unstemmed | Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses |
| title_short | Primary Breast Lymphoma in a Young Female: Non-Hodgkin’s Diffuse Large B-Cell Lymphoma in the Presence of Intact Breast Prostheses |
| title_sort | primary breast lymphoma in a young female non hodgkin s diffuse large b cell lymphoma in the presence of intact breast prostheses |
| url | https://karger.com/article/doi/10.1159/000543952 |
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