Identification of a Non-Retinoid Opsin Ligand Through Pharmacophore-Guided Virtual Screening—A Novel Potential Rhodopsin-Stabilizing Compound

Identification of a Non-Retinoid Opsin Ligand Through Pharmacophore-Guided Virtual Screening—A Novel Potential Rhodopsin-Stabilizing Compound

Rhodopsin, a G-protein-coupled receptor (GPCR) comprising the protein opsin covalently linked to the chromophore 11-cis retinal, is pivotal in visual phototransduction. Mutations in the gene encoding rhodopsin (RHO) can cause opsin misfolding or reduce its stability, resulting in retinal degenerativ...

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Bibliographic Details
Main Authors: Miriana Di Stefano, Maria Ghilardi, Clarissa Poles, Lisa Piazza, Gian Carlo Demontis, Giulio Poli, Tiziano Tuccinardi, Marco Macchia
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
rhodopsin
molecular chaperones
consensus docking
virtual screening
Online Access:https://www.mdpi.com/1420-3049/30/11/2328
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https://www.mdpi.com/1420-3049/30/11/2328

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