Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism
Objective: This study aimed to investigate the effect of aminooxyacetic acid (AOAA) on cognitive function, particularly learning and memory, in a rat model of chronic alcoholism. Additionally, the study explored changes in cystathionine β-synthase (CBS), hydrogen sulfide (H₂S), and serotonin (5-HT)...
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000152 |
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| author | Hongbo Jiang Xunling Wang Yingwei Liang Yinghan Hou Xinping Yue Zhiyi Zhang Dan Chen Xinyi Fan Ailin Du |
| author_facet | Hongbo Jiang Xunling Wang Yingwei Liang Yinghan Hou Xinping Yue Zhiyi Zhang Dan Chen Xinyi Fan Ailin Du |
| author_sort | Hongbo Jiang |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the effect of aminooxyacetic acid (AOAA) on cognitive function, particularly learning and memory, in a rat model of chronic alcoholism. Additionally, the study explored changes in cystathionine β-synthase (CBS), hydrogen sulfide (H₂S), and serotonin (5-HT) levels in the prefrontal cortex to understand the potential neurochemical mechanisms involved. Methods: Sixty-four male SD rats were randomly divided into four groups, with 16 rats in each: Con, Con + AOAA, Model, and Model + AOAA. The Model group received a 6 % ethanol solution for 28 days. From day 14, the Model + AOAA group was treated with daily intraperitoneal injections of AOAA (5 mg/kg) for 14 consecutive days. Cognitive function was assessed using the Morris water maze, mitochondrial function was evaluated through ATPase activity, and H₂S levels were measured. CBS and 5-HT levels in the prefrontal cortex were analyzed by immunohistochemistry. Results: Compared to the control groups, rats in the Model group exhibited significant impairments in learning and memory, increased CBS expression, elevated H₂S levels, and decreased 5-HT release. AOAA treatment improved memory performance, reduced CBS expression and H₂S levels, and increased 5-HT release, although these measures did not fully return to baseline. No significant differences were observed between the two control groups. Conclusion: AOAA may alleviate cognitive deficits associated with chronic alcoholism by inhibiting CBS expression, reducing H₂S levels, and enhancing 5-HT release in the prefrontal cortex. These findings suggest AOAA as a potential therapeutic strategy for alcohol-induced cognitive impairments. |
| format | Article |
| id | doaj-art-5fa3ade6b4314881a64f0ccb5b306c78 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-5fa3ade6b4314881a64f0ccb5b306c782025-02-07T04:46:42ZengElsevierBrain Research Bulletin1873-27472025-02-01221111203Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholismHongbo Jiang0Xunling Wang1Yingwei Liang2Yinghan Hou3Xinping Yue4Zhiyi Zhang5Dan Chen6Xinyi Fan7Ailin Du8Boao International Hospital, Qionghai, Hainan 469071, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, ChinaSino-UK International Joint Laboratory of Brain Injury in Henan Province, Henan International Joint Laboratory of Neuromodulation, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China; Correspondence to: Xinxiang Medical University, No. 601, Jinsui Road, Xinxiang, ChinaObjective: This study aimed to investigate the effect of aminooxyacetic acid (AOAA) on cognitive function, particularly learning and memory, in a rat model of chronic alcoholism. Additionally, the study explored changes in cystathionine β-synthase (CBS), hydrogen sulfide (H₂S), and serotonin (5-HT) levels in the prefrontal cortex to understand the potential neurochemical mechanisms involved. Methods: Sixty-four male SD rats were randomly divided into four groups, with 16 rats in each: Con, Con + AOAA, Model, and Model + AOAA. The Model group received a 6 % ethanol solution for 28 days. From day 14, the Model + AOAA group was treated with daily intraperitoneal injections of AOAA (5 mg/kg) for 14 consecutive days. Cognitive function was assessed using the Morris water maze, mitochondrial function was evaluated through ATPase activity, and H₂S levels were measured. CBS and 5-HT levels in the prefrontal cortex were analyzed by immunohistochemistry. Results: Compared to the control groups, rats in the Model group exhibited significant impairments in learning and memory, increased CBS expression, elevated H₂S levels, and decreased 5-HT release. AOAA treatment improved memory performance, reduced CBS expression and H₂S levels, and increased 5-HT release, although these measures did not fully return to baseline. No significant differences were observed between the two control groups. Conclusion: AOAA may alleviate cognitive deficits associated with chronic alcoholism by inhibiting CBS expression, reducing H₂S levels, and enhancing 5-HT release in the prefrontal cortex. These findings suggest AOAA as a potential therapeutic strategy for alcohol-induced cognitive impairments.http://www.sciencedirect.com/science/article/pii/S0361923025000152AOAA5-HTPrefrontal cortexHydrogen sulfideChronic alcoholism |
| spellingShingle | Hongbo Jiang Xunling Wang Yingwei Liang Yinghan Hou Xinping Yue Zhiyi Zhang Dan Chen Xinyi Fan Ailin Du Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism Brain Research Bulletin AOAA 5-HT Prefrontal cortex Hydrogen sulfide Chronic alcoholism |
| title | Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism |
| title_full | Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism |
| title_fullStr | Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism |
| title_full_unstemmed | Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism |
| title_short | Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism |
| title_sort | effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism |
| topic | AOAA 5-HT Prefrontal cortex Hydrogen sulfide Chronic alcoholism |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000152 |
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