Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest China
Abstract Objective Renal primitive neuroectodermal tumours (rPNETs) are extremely rare and highly aggressive malignancy, posing significant diagnostic and therapeutic challenges. This study aims to describe the clinicopathological characteristics, treatment strategies, and survival outcomes of 16 ca...
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Springer
2025-04-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-025-06210-0 |
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| author | Jing Du Bo Guo Jiayan Liu Zhenzhen Li Xilian Zhao Mingyu Shao Fan Yang |
| author_facet | Jing Du Bo Guo Jiayan Liu Zhenzhen Li Xilian Zhao Mingyu Shao Fan Yang |
| author_sort | Jing Du |
| collection | DOAJ |
| description | Abstract Objective Renal primitive neuroectodermal tumours (rPNETs) are extremely rare and highly aggressive malignancy, posing significant diagnostic and therapeutic challenges. This study aims to describe the clinicopathological characteristics, treatment strategies, and survival outcomes of 16 cases of rPNET from multiple centers in Northwest China, and to explore potential prognostic factors. Methods A multicenter retrospective study was conducted, including 16 patients diagnosed with rPNET across five hospitals in Northwest China. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were employed to assess the expression of molecular markers, including P53, BCL-2, Ki-67, and EWSR1 gene rearrangements. Survival analysis was performed using the Kaplan-Meier method, and prognostic factors were evaluated using univariate and multivariate Cox regression models. Results The median age of the patients was 39 years, with a median Ki-67 proliferation index of 50%. P53 mutations were detected in 87.0% of cases, and BCL-2 positive expression was observed in 56.25% of cases. The median overall survival (OS) was 14 months. Univariate analysis revealed that age, tumor stage, BCL-2 expression, and Ki-67 index were significantly associated with OS. Multivariate analysis identified high Ki-67 expression (HR = 1.100, 95% CI: 1.030–1.174, p = 0.004) and negative BCL-2 expression (HR = 0.151, 95% CI: 0.026–0.888, p = 0.037) as independent risk factors for poor prognosis. Kaplan-Meier survival curves demonstrated that the median OS was significantly shorter in patients with high Ki-67 expression (12 months) compared to those with low Ki-67 expression (20 months) (Log-rank test, P < 0.01). Similarly, the median OS was significantly shorter in the BCL-2 negative group (10 months) compared to the BCL-2 positive group (24 months) (Log-rank test, P < 0.05). Conclusion The absence of rosette structures does not exclude the diagnosis of rPNET. BCL-2 and Ki-67 expression are significant prognostic factors, with high Ki-67 expression and negative BCL-2 expression associated with worse outcomes. These findings highlight the importance of molecular markers in risk stratification and treatment planning for rPNET. |
| format | Article |
| id | doaj-art-5fa1fd434f184cb287815a9cbb2db38d |
| institution | OA Journals |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Springer |
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| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-5fa1fd434f184cb287815a9cbb2db38d2025-08-20T02:32:00ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-04-01151411210.1007/s00432-025-06210-0Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest ChinaJing Du0Bo Guo1Jiayan Liu2Zhenzhen Li3Xilian Zhao4Mingyu Shao5Fan Yang6Department of Pathology and Dermatology, Shaanxi Provincial People’s HospitalDepartment of Burns and Plastic Surgery, Tangdu Hospital of Air Force Medical UniversityXijing Hospital of Air Force Medical UniversityDepartment of Pathology and Dermatology, Shaanxi Provincial People’s HospitalDepartment of Pathology, Shaanxi Provincial Tumor HospitalDepartment of Pathology, Xinjiang Uygur Autonomous Region People’s HospitalDepartment of Pathology and Dermatology, Shaanxi Provincial People’s HospitalAbstract Objective Renal primitive neuroectodermal tumours (rPNETs) are extremely rare and highly aggressive malignancy, posing significant diagnostic and therapeutic challenges. This study aims to describe the clinicopathological characteristics, treatment strategies, and survival outcomes of 16 cases of rPNET from multiple centers in Northwest China, and to explore potential prognostic factors. Methods A multicenter retrospective study was conducted, including 16 patients diagnosed with rPNET across five hospitals in Northwest China. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were employed to assess the expression of molecular markers, including P53, BCL-2, Ki-67, and EWSR1 gene rearrangements. Survival analysis was performed using the Kaplan-Meier method, and prognostic factors were evaluated using univariate and multivariate Cox regression models. Results The median age of the patients was 39 years, with a median Ki-67 proliferation index of 50%. P53 mutations were detected in 87.0% of cases, and BCL-2 positive expression was observed in 56.25% of cases. The median overall survival (OS) was 14 months. Univariate analysis revealed that age, tumor stage, BCL-2 expression, and Ki-67 index were significantly associated with OS. Multivariate analysis identified high Ki-67 expression (HR = 1.100, 95% CI: 1.030–1.174, p = 0.004) and negative BCL-2 expression (HR = 0.151, 95% CI: 0.026–0.888, p = 0.037) as independent risk factors for poor prognosis. Kaplan-Meier survival curves demonstrated that the median OS was significantly shorter in patients with high Ki-67 expression (12 months) compared to those with low Ki-67 expression (20 months) (Log-rank test, P < 0.01). Similarly, the median OS was significantly shorter in the BCL-2 negative group (10 months) compared to the BCL-2 positive group (24 months) (Log-rank test, P < 0.05). Conclusion The absence of rosette structures does not exclude the diagnosis of rPNET. BCL-2 and Ki-67 expression are significant prognostic factors, with high Ki-67 expression and negative BCL-2 expression associated with worse outcomes. These findings highlight the importance of molecular markers in risk stratification and treatment planning for rPNET.https://doi.org/10.1007/s00432-025-06210-0rPNETKi-67BCL-2Prognostic factors |
| spellingShingle | Jing Du Bo Guo Jiayan Liu Zhenzhen Li Xilian Zhao Mingyu Shao Fan Yang Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest China Journal of Cancer Research and Clinical Oncology rPNET Ki-67 BCL-2 Prognostic factors |
| title | Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest China |
| title_full | Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest China |
| title_fullStr | Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest China |
| title_full_unstemmed | Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest China |
| title_short | Clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours: a multicentre retrospective study of 16 cases in Northwest China |
| title_sort | clinical pathological characteristics and prognostic analysis of renal primitive neuroectodermal tumours a multicentre retrospective study of 16 cases in northwest china |
| topic | rPNET Ki-67 BCL-2 Prognostic factors |
| url | https://doi.org/10.1007/s00432-025-06210-0 |
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