Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population
Aim: To determine the prevalence of ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and to characterize the risk factors associated with its development in a pediatric population. Methods: This retrospective chart review included 105 patients during a five-y...
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Elsevier
2025-04-01
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| Series: | Hematology, Transfusion and Cell Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137925000914 |
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| author | Cinthia Kim Patricia Cabral Zacharias Serapicos Cintia Monteiro Lustosa Adriane da Silva Santos Ibanez Victor Gottardello Zecchin Lauro Augusto de Oliveira |
| author_facet | Cinthia Kim Patricia Cabral Zacharias Serapicos Cintia Monteiro Lustosa Adriane da Silva Santos Ibanez Victor Gottardello Zecchin Lauro Augusto de Oliveira |
| author_sort | Cinthia Kim |
| collection | DOAJ |
| description | Aim: To determine the prevalence of ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and to characterize the risk factors associated with its development in a pediatric population. Methods: This retrospective chart review included 105 patients during a five-year period (2013–2017) from the Pediatric Oncology Institute (GRAACC-UNIFESP). The diagnosis of graft-versus-host disease was performed by the treating hematologist in conjunction with an ophthalmologist in accordance to National Institutes of Health (NIH) consensus criteria. Results: Systemic graft-versus-host disease occurred in 44 of 105 (41.9%) patients, predominantly in males (54.5%) whereas ocular disease was diagnosed in seven (6.7%) of the patients. All the analyzed risk factors including diagnosis, type of conditioning regimen, use of radiotherapy in conditioning, donor sex, type and source of graft, human leukocyte antigen mismatch, and sex mismatch were not statistically significantly associated with the development of ocular disease, except for age. Ocular graft-versus-host disease patients presented a higher mean age compared to patients without ocular disease (p-value = 0.015). Conclusion: Although less prevalent than in adults, ocular morbidity remains a concern in pediatric patients following allogeneic transplantation. Early diagnosis and regular ophthalmic follow-ups are recommended after the transplantation regardless of systemic graft-versus-host disease status. |
| format | Article |
| id | doaj-art-5fa0ed545adb42fa83b0a96c79f02853 |
| institution | DOAJ |
| issn | 2531-1379 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-5fa0ed545adb42fa83b0a96c79f028532025-08-20T03:08:28ZengElsevierHematology, Transfusion and Cell Therapy2531-13792025-04-0147210382310.1016/j.htct.2025.103823Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric populationCinthia Kim0Patricia Cabral Zacharias Serapicos1Cintia Monteiro Lustosa2Adriane da Silva Santos Ibanez3Victor Gottardello Zecchin4Lauro Augusto de Oliveira5Department of Ophthalmology and Visual Sciences, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Corresponding author.Department of Ophthalmology and Visual Sciences, Federal University of São Paulo (UNIFESP), São Paulo, BrazilPediatric Oncology Institute, GRAACC, Federal University of São Paulo (UNIFESP), São Paulo, BrazilPediatric Oncology Institute, GRAACC, Federal University of São Paulo (UNIFESP), São Paulo, BrazilPediatric Oncology Institute, GRAACC, Federal University of São Paulo (UNIFESP), São Paulo, BrazilDepartment of Ophthalmology and Visual Sciences, Federal University of São Paulo (UNIFESP), São Paulo, BrazilAim: To determine the prevalence of ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and to characterize the risk factors associated with its development in a pediatric population. Methods: This retrospective chart review included 105 patients during a five-year period (2013–2017) from the Pediatric Oncology Institute (GRAACC-UNIFESP). The diagnosis of graft-versus-host disease was performed by the treating hematologist in conjunction with an ophthalmologist in accordance to National Institutes of Health (NIH) consensus criteria. Results: Systemic graft-versus-host disease occurred in 44 of 105 (41.9%) patients, predominantly in males (54.5%) whereas ocular disease was diagnosed in seven (6.7%) of the patients. All the analyzed risk factors including diagnosis, type of conditioning regimen, use of radiotherapy in conditioning, donor sex, type and source of graft, human leukocyte antigen mismatch, and sex mismatch were not statistically significantly associated with the development of ocular disease, except for age. Ocular graft-versus-host disease patients presented a higher mean age compared to patients without ocular disease (p-value = 0.015). Conclusion: Although less prevalent than in adults, ocular morbidity remains a concern in pediatric patients following allogeneic transplantation. Early diagnosis and regular ophthalmic follow-ups are recommended after the transplantation regardless of systemic graft-versus-host disease status.http://www.sciencedirect.com/science/article/pii/S2531137925000914Graft-versus-host diseaseHematopoietic stem cell transplantationOcular graft-versus-host diseaseDry eye |
| spellingShingle | Cinthia Kim Patricia Cabral Zacharias Serapicos Cintia Monteiro Lustosa Adriane da Silva Santos Ibanez Victor Gottardello Zecchin Lauro Augusto de Oliveira Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population Hematology, Transfusion and Cell Therapy Graft-versus-host disease Hematopoietic stem cell transplantation Ocular graft-versus-host disease Dry eye |
| title | Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population |
| title_full | Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population |
| title_fullStr | Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population |
| title_full_unstemmed | Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population |
| title_short | Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population |
| title_sort | ocular graft versus host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population |
| topic | Graft-versus-host disease Hematopoietic stem cell transplantation Ocular graft-versus-host disease Dry eye |
| url | http://www.sciencedirect.com/science/article/pii/S2531137925000914 |
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