Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration

Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration

Abstract The colon epithelium frequently incurs damage through toxic influences. Repair is rapid, mediated by cellular plasticity and acquisition of the highly proliferative regenerative state. However, the mechanisms that promote the regenerative state are not well understood. Here, we reveal that...

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Main Authors: Julian Heuberger, Lichao Liu, Hilmar Berger, Joop van den Heuvel, Manqiang Lin, Stefanie Müllerke, Safak Bayram, Giulia Beccaceci, Hugo de Jonge, Ermanno Gherardi, Michael Sigal
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59474-y
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