Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability
This work presents an innovative bioimpedance spectroscopy device, developed as a support tool for decision-making during the evaluation of kidney viability for renal transplantation. Given the increasing demand for organs and the need to optimize donation criteria, the precise and objective assessm...
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| Format: | Article |
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/1424-8220/25/9/2871 |
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| author | David Naranjo-Hernández Javier Reina-Tosina Laura M. Roa Gerardo Barbarov-Rostán Jorge Calvillo-Arbizu Alejandro Talaminos-Barroso Miguel Ángel Pérez-Valdivia Rafael A. Medina-López |
| author_facet | David Naranjo-Hernández Javier Reina-Tosina Laura M. Roa Gerardo Barbarov-Rostán Jorge Calvillo-Arbizu Alejandro Talaminos-Barroso Miguel Ángel Pérez-Valdivia Rafael A. Medina-López |
| author_sort | David Naranjo-Hernández |
| collection | DOAJ |
| description | This work presents an innovative bioimpedance spectroscopy device, developed as a support tool for decision-making during the evaluation of kidney viability for renal transplantation. Given the increasing demand for organs and the need to optimize donation criteria, the precise and objective assessment of renal graft functionality has become crucial. The device, based on a modular design and adapted to the surgical environment, uses a novel Cole model with a frequency-dependent membrane capacitance, which improves measurement accuracy and repeatability compared to conventional models. Adapting the device for operating room usege involved overcoming significant challenges, such as the need for sterilization and a visual, tactile and acoustic user interface that facilitates device usability. Optimizing the sensing stage has minimized the influence of measurement artifacts, which is crucial for obtaining accurate and representative measurements of renal tissue bioelectrical properties. In addition, a rigorous electrode sterilization protocol was designed, ensuring asepsis during the procedure. The results of tests on porcine renal models demonstrated the device’s ability to monitor pathophysiological changes associated with renal ischemia, with a notable improvement against measurement repeatability. |
| format | Article |
| id | doaj-art-5f96178aeab84dd7b08b8920afb34d15 |
| institution | DOAJ |
| issn | 1424-8220 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj-art-5f96178aeab84dd7b08b8920afb34d152025-08-20T02:58:48ZengMDPI AGSensors1424-82202025-05-01259287110.3390/s25092871Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft ViabilityDavid Naranjo-Hernández0Javier Reina-Tosina1Laura M. Roa2Gerardo Barbarov-Rostán3Jorge Calvillo-Arbizu4Alejandro Talaminos-Barroso5Miguel Ángel Pérez-Valdivia6Rafael A. Medina-López7Biomedical Engineering Group, Department of Signal Theory and Communications, University of Seville, 41092 Seville, SpainBiomedical Engineering Group, Department of Signal Theory and Communications, University of Seville, 41092 Seville, SpainBiomedical Engineering Group, Department of Signal Theory and Communications, University of Seville, 41092 Seville, SpainBiomedical Engineering Group, Department of Signal Theory and Communications, University of Seville, 41092 Seville, SpainBiomedical Engineering Group, Department of Signal Theory and Communications, University of Seville, 41092 Seville, SpainBiomedical Engineering Group, Department of Signal Theory and Communications, University of Seville, 41092 Seville, SpainClinical Management Unit of Urology and Nephrology, Virgen del Rocío University Hospital, 41013 Seville, SpainClinical Management Unit of Urology and Nephrology, Virgen del Rocío University Hospital, 41013 Seville, SpainThis work presents an innovative bioimpedance spectroscopy device, developed as a support tool for decision-making during the evaluation of kidney viability for renal transplantation. Given the increasing demand for organs and the need to optimize donation criteria, the precise and objective assessment of renal graft functionality has become crucial. The device, based on a modular design and adapted to the surgical environment, uses a novel Cole model with a frequency-dependent membrane capacitance, which improves measurement accuracy and repeatability compared to conventional models. Adapting the device for operating room usege involved overcoming significant challenges, such as the need for sterilization and a visual, tactile and acoustic user interface that facilitates device usability. Optimizing the sensing stage has minimized the influence of measurement artifacts, which is crucial for obtaining accurate and representative measurements of renal tissue bioelectrical properties. In addition, a rigorous electrode sterilization protocol was designed, ensuring asepsis during the procedure. The results of tests on porcine renal models demonstrated the device’s ability to monitor pathophysiological changes associated with renal ischemia, with a notable improvement against measurement repeatability.https://www.mdpi.com/1424-8220/25/9/2871bioimpedance spectroscopyCole modelkidney transplantischemia monitoring |
| spellingShingle | David Naranjo-Hernández Javier Reina-Tosina Laura M. Roa Gerardo Barbarov-Rostán Jorge Calvillo-Arbizu Alejandro Talaminos-Barroso Miguel Ángel Pérez-Valdivia Rafael A. Medina-López Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability Sensors bioimpedance spectroscopy Cole model kidney transplant ischemia monitoring |
| title | Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability |
| title_full | Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability |
| title_fullStr | Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability |
| title_full_unstemmed | Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability |
| title_short | Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability |
| title_sort | development and validation in porcine and human models of a bioimpedance spectroscopy system for the objective assessment of kidney graft viability |
| topic | bioimpedance spectroscopy Cole model kidney transplant ischemia monitoring |
| url | https://www.mdpi.com/1424-8220/25/9/2871 |
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