Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations
Mei Yu,1,* ChengZheng Zhang,1,* ZhengTong Wang,2,* ShaoWen Lv,3 YiFang Sun,1 WenWen Zhao,4 Lu Li,5 QingFeng Kong,3 Kun Liu,1 Shuanglong Wang3 1Department of Ultrasound Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Repu...
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Dove Medical Press
2025-03-01
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| author | Yu M Zhang C Wang Z Lv S Sun Y Zhao W Li L Kong Q Liu K Wang S |
| author_facet | Yu M Zhang C Wang Z Lv S Sun Y Zhao W Li L Kong Q Liu K Wang S |
| author_sort | Yu M |
| collection | DOAJ |
| description | Mei Yu,1,* ChengZheng Zhang,1,* ZhengTong Wang,2,* ShaoWen Lv,3 YiFang Sun,1 WenWen Zhao,4 Lu Li,5 QingFeng Kong,3 Kun Liu,1 Shuanglong Wang3 1Department of Ultrasound Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China; 2Department of Radiology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China; 3Department of Ultrasound Medicine, Jining NO.1 People’s Hospital, Jining, Shandong Province, 272000, People’s Republic of China; 4Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China; 5Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuanglong Wang, Department of Ultrasound Medicine, Jining NO.1 People’s Hospital, No. 6 Jiankang Road, Jining, Shandong Province, 272000, People’s Republic of China, Tel +86 15153740602, Email tywshl@163.com Kun Liu, Department of Ultrasound Medicine, Affiliated Hospital of Jining Medical University, No. 89 Guhuai Road, Jining, Shandong Province, 272000, People’s Republic of China, Tel +86 15264766616, Email 46314346@qq.comPurpose: The coexistence of TERT promoter and BRAFV600E mutations is strongly linked to aggressive behavior and poor prognosis in papillary thyroid carcinoma (PTC). This study aimed to develop preoperative and postoperative predictive models for coexisting mutations based on ultrasound and clinicopathological characteristics to stratify prognostic risks and guide clinical decision-making.Methods: Retrospective analysis of the ultrasound and clinicopathological characteristics of 120 patients with a surgical pathology of PTC with TERT promoter and BRAFV600E gene testing results in the Affiliated Hospital of Jining Medical University from December 2020 to December 2023. Univariate and multivariate logistic regression identified independent predictors, and nomograms were constructed. Model performance was evaluated using ROC curves, calibration curves, and decision curves, with internal validation via Bootstrap resampling.Results: Age (OR: 1.24; 95% CI 1.12– 1.37, P< 0.001), tumor size (OR: 5.51; 95% CI 2.26– 13.46, P< 0.001), lateral lymph node metastasis (OR: 7.36; 95% CI 1.48– 36.48, P=0.015), and irregular/ill-defined margins (OR: 6.06; 95% CI 1.19– 30.75, P=0.030) were independent predictors of coexisting mutations. The cutoff values for age and tumor size were 44.5 years and 1.55 cm, respectively. Two models incorporating the four independent predictors were established to predict coexisting mutations in the preoperative and postoperative periods, achieving AUCs of 0.95 and 0.96, respectively, with both models demonstrating good calibration ability and clinical practicability through calibration and decision curve analyses.Conclusion: The predictive models enable clinicians to identify high-risk patients with coexisting mutations both preoperatively and postoperatively, supporting the development of individualized treatment strategies and potentially improving patient outcomes. However, the study is limited by its single-center design, and further external validation is needed to confirm the generalizability of the model.Keywords: ultrasound and clinicopathological characteristics, coexistence of TERT promoter and BRAFV600E mutations, papillary thyroid carcinoma, predictive model, risk stratification |
| format | Article |
| id | doaj-art-5f921ccc99da4ab28c7f9709749b43d0 |
| institution | DOAJ |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj-art-5f921ccc99da4ab28c7f9709749b43d02025-08-20T02:40:41ZengDove Medical PressInternational Journal of General Medicine1178-70742025-03-01Volume 1816431656101411Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E MutationsYu MZhang CWang ZLv SSun YZhao WLi LKong QLiu KWang SMei Yu,1,* ChengZheng Zhang,1,* ZhengTong Wang,2,* ShaoWen Lv,3 YiFang Sun,1 WenWen Zhao,4 Lu Li,5 QingFeng Kong,3 Kun Liu,1 Shuanglong Wang3 1Department of Ultrasound Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China; 2Department of Radiology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China; 3Department of Ultrasound Medicine, Jining NO.1 People’s Hospital, Jining, Shandong Province, 272000, People’s Republic of China; 4Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China; 5Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, 272000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuanglong Wang, Department of Ultrasound Medicine, Jining NO.1 People’s Hospital, No. 6 Jiankang Road, Jining, Shandong Province, 272000, People’s Republic of China, Tel +86 15153740602, Email tywshl@163.com Kun Liu, Department of Ultrasound Medicine, Affiliated Hospital of Jining Medical University, No. 89 Guhuai Road, Jining, Shandong Province, 272000, People’s Republic of China, Tel +86 15264766616, Email 46314346@qq.comPurpose: The coexistence of TERT promoter and BRAFV600E mutations is strongly linked to aggressive behavior and poor prognosis in papillary thyroid carcinoma (PTC). This study aimed to develop preoperative and postoperative predictive models for coexisting mutations based on ultrasound and clinicopathological characteristics to stratify prognostic risks and guide clinical decision-making.Methods: Retrospective analysis of the ultrasound and clinicopathological characteristics of 120 patients with a surgical pathology of PTC with TERT promoter and BRAFV600E gene testing results in the Affiliated Hospital of Jining Medical University from December 2020 to December 2023. Univariate and multivariate logistic regression identified independent predictors, and nomograms were constructed. Model performance was evaluated using ROC curves, calibration curves, and decision curves, with internal validation via Bootstrap resampling.Results: Age (OR: 1.24; 95% CI 1.12– 1.37, P< 0.001), tumor size (OR: 5.51; 95% CI 2.26– 13.46, P< 0.001), lateral lymph node metastasis (OR: 7.36; 95% CI 1.48– 36.48, P=0.015), and irregular/ill-defined margins (OR: 6.06; 95% CI 1.19– 30.75, P=0.030) were independent predictors of coexisting mutations. The cutoff values for age and tumor size were 44.5 years and 1.55 cm, respectively. Two models incorporating the four independent predictors were established to predict coexisting mutations in the preoperative and postoperative periods, achieving AUCs of 0.95 and 0.96, respectively, with both models demonstrating good calibration ability and clinical practicability through calibration and decision curve analyses.Conclusion: The predictive models enable clinicians to identify high-risk patients with coexisting mutations both preoperatively and postoperatively, supporting the development of individualized treatment strategies and potentially improving patient outcomes. However, the study is limited by its single-center design, and further external validation is needed to confirm the generalizability of the model.Keywords: ultrasound and clinicopathological characteristics, coexistence of TERT promoter and BRAFV600E mutations, papillary thyroid carcinoma, predictive model, risk stratificationhttps://www.dovepress.com/ultrasound-and-clinicopathological-characteristics-of-papillary-thyroi-peer-reviewed-fulltext-article-IJGMultrasound and clinicopathological characteristicscoexistence of tert promoter and brafv600e mutationspapillary thyroid carcinomapredictive modelrisk stratification |
| spellingShingle | Yu M Zhang C Wang Z Lv S Sun Y Zhao W Li L Kong Q Liu K Wang S Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations International Journal of General Medicine ultrasound and clinicopathological characteristics coexistence of tert promoter and brafv600e mutations papillary thyroid carcinoma predictive model risk stratification |
| title | Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations |
| title_full | Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations |
| title_fullStr | Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations |
| title_full_unstemmed | Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations |
| title_short | Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations |
| title_sort | ultrasound and clinicopathological characteristics of papillary thyroid carcinoma predict the coexistence of tert promoter and brafv600e mutations |
| topic | ultrasound and clinicopathological characteristics coexistence of tert promoter and brafv600e mutations papillary thyroid carcinoma predictive model risk stratification |
| url | https://www.dovepress.com/ultrasound-and-clinicopathological-characteristics-of-papillary-thyroi-peer-reviewed-fulltext-article-IJGM |
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