DNA-protein cross-links emerge as major contributors to chemotherapeutic cytotoxicity at physiological equitoxic doses

DNA-protein cross-links emerge as major contributors to chemotherapeutic cytotoxicity at physiological equitoxic doses

Abstract Chemotherapeutic drugs induce DNA damage, including double-strand breaks (DSBs), interstrand cross-links (ICLs), and DNA-protein cross-links (DPCs), to inhibit cancer cell proliferation. Understanding the relative contributions of these damages is essential for optimizing therapeutic strate...

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Bibliographic Details
Main Authors: Mahmoud I. Shoulkamy, Tareg Omer Mohammed, Hiroshi Ide, Toshiaki Nakano
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
DNA damage
Chemotherapeutic drugs
Cytotoxicity
Equitoxic dose
Cancer therapies
Online Access:https://doi.org/10.1038/s41598-025-06705-3
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