2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.
<h4>Background</h4>In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strai...
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| Language: | English |
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Public Library of Science (PLoS)
2009-07-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006402&type=printable |
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| author | Carl Kingsford Niranjan Nagarajan Steven L Salzberg |
| author_facet | Carl Kingsford Niranjan Nagarajan Steven L Salzberg |
| author_sort | Carl Kingsford |
| collection | DOAJ |
| description | <h4>Background</h4>In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact.<h4>Methodology</h4>We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1).<h4>Significance</h4>Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans. |
| format | Article |
| id | doaj-art-5f8f75ddea8540f9bb23e82da222fff5 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2009-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5f8f75ddea8540f9bb23e82da222fff52025-08-20T02:38:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-07-0147e640210.1371/journal.pone.00064022009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.Carl KingsfordNiranjan NagarajanSteven L Salzberg<h4>Background</h4>In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact.<h4>Methodology</h4>We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1).<h4>Significance</h4>Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006402&type=printable |
| spellingShingle | Carl Kingsford Niranjan Nagarajan Steven L Salzberg 2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates. PLoS ONE |
| title | 2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates. |
| title_full | 2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates. |
| title_fullStr | 2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates. |
| title_full_unstemmed | 2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates. |
| title_short | 2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates. |
| title_sort | 2009 swine origin influenza a h1n1 resembles previous influenza isolates |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006402&type=printable |
| work_keys_str_mv | AT carlkingsford 2009swineorigininfluenzaah1n1resemblespreviousinfluenzaisolates AT niranjannagarajan 2009swineorigininfluenzaah1n1resemblespreviousinfluenzaisolates AT stevenlsalzberg 2009swineorigininfluenzaah1n1resemblespreviousinfluenzaisolates |