Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway
Abstract Loss of skeletal muscle mass and strength can result from various factors, including malnutrition, glucocorticoid usage, and diseases. The mealworm (Tenebrio molitor larvae) is an edible insect gaining popularity as an alternative protein-rich diet. Mealworms are expected to help alleviate...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00432-9 |
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| author | Sung-Min Kim Jong-Yeon Kim Eun-Min Jun Varun Jaiswal Eun-Jung Park Hae-Jeung Lee |
| author_facet | Sung-Min Kim Jong-Yeon Kim Eun-Min Jun Varun Jaiswal Eun-Jung Park Hae-Jeung Lee |
| author_sort | Sung-Min Kim |
| collection | DOAJ |
| description | Abstract Loss of skeletal muscle mass and strength can result from various factors, including malnutrition, glucocorticoid usage, and diseases. The mealworm (Tenebrio molitor larvae) is an edible insect gaining popularity as an alternative protein-rich diet. Mealworms are expected to help alleviate muscle atrophy based on their rich, high-quality protein and peptide content, but it remains unclear whether mealworms ameliorate muscle loss. This study aimed to investigate the potential of mealworm hydrolysate (MH) in mitigating dexamethasone (DEX)-induced muscle atrophy and to elucidate the underlying mechanisms. MH ameliorates muscle atrophy by activating sirtuin 1 (SIRT1) and Akt, reducing muscle-specific RING finger protein-1 and atrogin-1 expression, and inhibiting apoptosis in DEX-treated C2C12 cells. Additionally, MH significantly increased the muscle mass, grip strength, and muscle fiber cross-sectional area by activating SIRT1 and Akt in DEX-treated rats. These findings suggest that MH has the potential in alleviating dexamethasone-induced muscle atrophy. |
| format | Article |
| id | doaj-art-5f88efb687754b75ab55ecef2c590db1 |
| institution | OA Journals |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-5f88efb687754b75ab55ecef2c590db12025-08-20T02:25:17ZengNature Portfolionpj Science of Food2396-83702025-05-019111110.1038/s41538-025-00432-9Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathwaySung-Min Kim0Jong-Yeon Kim1Eun-Min Jun2Varun Jaiswal3Eun-Jung Park4Hae-Jeung Lee5Department of Food Science and Biotechnology, Gachon UniversityDepartment of Food Science and Biotechnology, Gachon UniversityDepartment of Food and Nutrition, Gachon UniversityInstitute for Aging and Clinical Nutrition research, Gachon UniversityInstitute for Aging and Clinical Nutrition research, Gachon UniversityDepartment of Food Science and Biotechnology, Gachon UniversityAbstract Loss of skeletal muscle mass and strength can result from various factors, including malnutrition, glucocorticoid usage, and diseases. The mealworm (Tenebrio molitor larvae) is an edible insect gaining popularity as an alternative protein-rich diet. Mealworms are expected to help alleviate muscle atrophy based on their rich, high-quality protein and peptide content, but it remains unclear whether mealworms ameliorate muscle loss. This study aimed to investigate the potential of mealworm hydrolysate (MH) in mitigating dexamethasone (DEX)-induced muscle atrophy and to elucidate the underlying mechanisms. MH ameliorates muscle atrophy by activating sirtuin 1 (SIRT1) and Akt, reducing muscle-specific RING finger protein-1 and atrogin-1 expression, and inhibiting apoptosis in DEX-treated C2C12 cells. Additionally, MH significantly increased the muscle mass, grip strength, and muscle fiber cross-sectional area by activating SIRT1 and Akt in DEX-treated rats. These findings suggest that MH has the potential in alleviating dexamethasone-induced muscle atrophy.https://doi.org/10.1038/s41538-025-00432-9 |
| spellingShingle | Sung-Min Kim Jong-Yeon Kim Eun-Min Jun Varun Jaiswal Eun-Jung Park Hae-Jeung Lee Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway npj Science of Food |
| title | Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway |
| title_full | Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway |
| title_fullStr | Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway |
| title_full_unstemmed | Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway |
| title_short | Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway |
| title_sort | mealworm hydrolysate ameliorates dexamethasone induced muscle atrophy via sirtuin 1 mediated signaling and akt pathway |
| url | https://doi.org/10.1038/s41538-025-00432-9 |
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