Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome
Objective. To examine the association of polycystic ovary syndrome (PCOS) in early pregnancy with gestational diabetes mellitus (GDM) and adverse birth outcomes. Methods. In this retrospective cohort study including 2389 pregnant women, the medical records of 352 women diagnosed with PCOS were evalu...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/5787104 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550698420535296 |
|---|---|
| author | Qing Xiao Yong-Yi Cui Jine Lu Guo-Zheng Zhang Fang-Ling Zeng |
| author_facet | Qing Xiao Yong-Yi Cui Jine Lu Guo-Zheng Zhang Fang-Ling Zeng |
| author_sort | Qing Xiao |
| collection | DOAJ |
| description | Objective. To examine the association of polycystic ovary syndrome (PCOS) in early pregnancy with gestational diabetes mellitus (GDM) and adverse birth outcomes. Methods. In this retrospective cohort study including 2389 pregnant women, the medical records of 352 women diagnosed with PCOS were evaluated. Outcomes included GDM, preterm birth, low birth weight, macrosomia, and being small and large for gestational age. Multivariable logistic regression models were used to examine the association of the risk for GDM and adverse birth outcomes with PCOS after adjusting for confounders. Results. Women previously diagnosed with PCOS had a higher risk of GDM (adjusted odds ratio [OR] 1.55, 95% confidence interval [CI]: 1.14–2.09). A strong association was seen between PCOS and preterm birth (adjusted OR 1.69, 95% CI: 1.08–2.67). On stratified analysis, the adjusted OR for GDM among women with PCOS undergoing assisted reproductive technology was 1.44 (95% CI: 1.03–1.92) and among women with PCOS who conceived spontaneously was 1.60 (1.18–2.15). No increased risk for other adverse birth outcomes was observed. Conclusions. Women with PCOS were more likely to experience GDM and preterm birth. |
| format | Article |
| id | doaj-art-5f889859e47e4ebebf7be6f252809904 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5f889859e47e4ebebf7be6f2528099042025-02-03T06:06:06ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/57871045787104Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary SyndromeQing Xiao0Yong-Yi Cui1Jine Lu2Guo-Zheng Zhang3Fang-Ling Zeng4Department of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaObjective. To examine the association of polycystic ovary syndrome (PCOS) in early pregnancy with gestational diabetes mellitus (GDM) and adverse birth outcomes. Methods. In this retrospective cohort study including 2389 pregnant women, the medical records of 352 women diagnosed with PCOS were evaluated. Outcomes included GDM, preterm birth, low birth weight, macrosomia, and being small and large for gestational age. Multivariable logistic regression models were used to examine the association of the risk for GDM and adverse birth outcomes with PCOS after adjusting for confounders. Results. Women previously diagnosed with PCOS had a higher risk of GDM (adjusted odds ratio [OR] 1.55, 95% confidence interval [CI]: 1.14–2.09). A strong association was seen between PCOS and preterm birth (adjusted OR 1.69, 95% CI: 1.08–2.67). On stratified analysis, the adjusted OR for GDM among women with PCOS undergoing assisted reproductive technology was 1.44 (95% CI: 1.03–1.92) and among women with PCOS who conceived spontaneously was 1.60 (1.18–2.15). No increased risk for other adverse birth outcomes was observed. Conclusions. Women with PCOS were more likely to experience GDM and preterm birth.http://dx.doi.org/10.1155/2016/5787104 |
| spellingShingle | Qing Xiao Yong-Yi Cui Jine Lu Guo-Zheng Zhang Fang-Ling Zeng Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome International Journal of Endocrinology |
| title | Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome |
| title_full | Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome |
| title_fullStr | Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome |
| title_short | Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome |
| title_sort | risk for gestational diabetes mellitus and adverse birth outcomes in chinese women with polycystic ovary syndrome |
| url | http://dx.doi.org/10.1155/2016/5787104 |
| work_keys_str_mv | AT qingxiao riskforgestationaldiabetesmellitusandadversebirthoutcomesinchinesewomenwithpolycysticovarysyndrome AT yongyicui riskforgestationaldiabetesmellitusandadversebirthoutcomesinchinesewomenwithpolycysticovarysyndrome AT jinelu riskforgestationaldiabetesmellitusandadversebirthoutcomesinchinesewomenwithpolycysticovarysyndrome AT guozhengzhang riskforgestationaldiabetesmellitusandadversebirthoutcomesinchinesewomenwithpolycysticovarysyndrome AT fanglingzeng riskforgestationaldiabetesmellitusandadversebirthoutcomesinchinesewomenwithpolycysticovarysyndrome |