The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats
Rheumatoid arthritis (RA) is associated with comorbidities like dyslipidemia and liver damage. Acorus calamus L. is commonly used to treat inflammatory and hepatorenal ailments. Herein, we assessed the hypolipidemic and hepatoprotective activities of A. calamus rhizome extracts in adjuvant-induced a...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Applied Animal Research |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09712119.2024.2402045 |
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| author | Muhammad Usman Bari Bilal Aslam Faisal Muhammad Naeem Asif Hussain Wafa Majeed Ibrahim A. Alhidary Samia H. Abdelrahman Simona Taricone |
| author_facet | Muhammad Usman Bari Bilal Aslam Faisal Muhammad Naeem Asif Hussain Wafa Majeed Ibrahim A. Alhidary Samia H. Abdelrahman Simona Taricone |
| author_sort | Muhammad Usman Bari |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is associated with comorbidities like dyslipidemia and liver damage. Acorus calamus L. is commonly used to treat inflammatory and hepatorenal ailments. Herein, we assessed the hypolipidemic and hepatoprotective activities of A. calamus rhizome extracts in adjuvant-induced arthritis (AIA) in rats. A. calamus rhizome’s methanol (AME) and n-hexane (AHE) extracts were prepared. In vivo, fifty-four female Wistar rats were allocated into nine groups (n = 6). The AIA was induced by injecting Complete Freund’s adjuvant (100 µL, s.c.) into the rat’s right hind paw. After AIA induction, animals were orally treated with meloxicam (MEL; 3 mg/kg) and graded doses (125, 250, and 500 mg/kg) of AME and AHE for 28 consecutive days. Results showed that both plant extracts dose-dependently restored the body weight and liver index of arthritic rats. Each plant extract significantly (p < 0.05) attenuated hyperlipidemia and atherogenicity in arthritic rats. They also normalized the liver function markers and protein concentrations along with the reduction in hepatic oxidative stress. Histopathological examination of the liver supported the biochemical findings. However, AME exhibited better pharmacological activities than AHE. Our findings conclude that A. calamus rhizome could be used to treat dyslipidemia and liver injury in inflammatory conditions like RA. |
| format | Article |
| id | doaj-art-5f871da4b36743b98fc477f15d3148b1 |
| institution | OA Journals |
| issn | 0971-2119 0974-1844 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Applied Animal Research |
| spelling | doaj-art-5f871da4b36743b98fc477f15d3148b12025-08-20T02:32:08ZengTaylor & Francis GroupJournal of Applied Animal Research0971-21190974-18442024-12-0152110.1080/09712119.2024.2402045The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in ratsMuhammad Usman Bari0Bilal Aslam1Faisal Muhammad Naeem2Asif Hussain3Wafa Majeed4Ibrahim A. Alhidary5Samia H. Abdelrahman6Simona Taricone7Institute of Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, PakistanInstitute of Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, PakistanInstitute of Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, PakistanInstitute of Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, PakistanDepartment of Pharmacy, University of Agriculture Faisalabad, Faisalabad, PakistanDepartment of Animal Production, College of Food and Agriculture Science, King Saud University, Riyadh, Saudi ArabiaVeterinary Research Laboratory, Khartoum, SudanDepartment of Soil, Plant and Food, University of Bari, Aldo Moro, ItalyRheumatoid arthritis (RA) is associated with comorbidities like dyslipidemia and liver damage. Acorus calamus L. is commonly used to treat inflammatory and hepatorenal ailments. Herein, we assessed the hypolipidemic and hepatoprotective activities of A. calamus rhizome extracts in adjuvant-induced arthritis (AIA) in rats. A. calamus rhizome’s methanol (AME) and n-hexane (AHE) extracts were prepared. In vivo, fifty-four female Wistar rats were allocated into nine groups (n = 6). The AIA was induced by injecting Complete Freund’s adjuvant (100 µL, s.c.) into the rat’s right hind paw. After AIA induction, animals were orally treated with meloxicam (MEL; 3 mg/kg) and graded doses (125, 250, and 500 mg/kg) of AME and AHE for 28 consecutive days. Results showed that both plant extracts dose-dependently restored the body weight and liver index of arthritic rats. Each plant extract significantly (p < 0.05) attenuated hyperlipidemia and atherogenicity in arthritic rats. They also normalized the liver function markers and protein concentrations along with the reduction in hepatic oxidative stress. Histopathological examination of the liver supported the biochemical findings. However, AME exhibited better pharmacological activities than AHE. Our findings conclude that A. calamus rhizome could be used to treat dyslipidemia and liver injury in inflammatory conditions like RA.https://www.tandfonline.com/doi/10.1080/09712119.2024.2402045Acorus calamushyperlipidemialiver injuryoxidative stressrheumatoid arthritis |
| spellingShingle | Muhammad Usman Bari Bilal Aslam Faisal Muhammad Naeem Asif Hussain Wafa Majeed Ibrahim A. Alhidary Samia H. Abdelrahman Simona Taricone The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats Journal of Applied Animal Research Acorus calamus hyperlipidemia liver injury oxidative stress rheumatoid arthritis |
| title | The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats |
| title_full | The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats |
| title_fullStr | The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats |
| title_full_unstemmed | The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats |
| title_short | The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats |
| title_sort | protective effects of acorus calamus l rhizome extracts against rheumatoid arthritis associated dyslipidemia oxidative stress and liver injury in rats |
| topic | Acorus calamus hyperlipidemia liver injury oxidative stress rheumatoid arthritis |
| url | https://www.tandfonline.com/doi/10.1080/09712119.2024.2402045 |
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