Impact of climate change on adipose-derived stem cells: A molecular and histological study
Background: Climate change, particularly temperature and humidity fluctuations, can affect biological systems. This study specifically investigates the impact of these two key aspects of climate change on adipose-derived stem cells (ADSCs) as a pilot study and starting point for further examinations...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | The Journal of Climate Change and Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667278224000701 |
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| author | Saeed Motesaddi Zarandi Rasoul Yarahmadi Rasul Nasiri Mohammad Bayat Hossein Nasiri Abdollah Amini Mohammad Esmaeil Motlagh Hassan Rasoulzadeh |
| author_facet | Saeed Motesaddi Zarandi Rasoul Yarahmadi Rasul Nasiri Mohammad Bayat Hossein Nasiri Abdollah Amini Mohammad Esmaeil Motlagh Hassan Rasoulzadeh |
| author_sort | Saeed Motesaddi Zarandi |
| collection | DOAJ |
| description | Background: Climate change, particularly temperature and humidity fluctuations, can affect biological systems. This study specifically investigates the impact of these two key aspects of climate change on adipose-derived stem cells (ADSCs) as a pilot study and starting point for further examinations into the biological effects of climate change-associated conditions. Methods: One-month-old male rats were kept for 4 months (equal to a 10-year climatic period) in 4 groups and exposed to conditions based on climatic data from Tehran's synoptic stations. Rats in the control group were exposed to conditions based on climatic data from 1991, and groups 2–4 were exposed to conditions based on climatic data from 1991 to 2000, 2001–2010, and 2011–2020, respectively. Monthly temperature, humidity, and day/night cycle averages were selected for animal exposure. After exposure, fat-derived stem cells were taken from each subject and assays assessing reactive oxygen species (ROS), cell viability and proliferation, and apoptosis were performed. Results: From 1991 to 2020, Tehran experienced an average temperature increase of 1.5 °C and a 15 % decrease in average humidity, conditions which when replicated in rodent models were associated with increased rates of ROS and caspase-3 expression, a reduction in Ki-67 antigen expression and in the duration of the life of cells, and an increase in the rate of apoptosis, such that apoptosis in ADSCs reached 25.51 %. Conclusion: The study demonstrates that environmental conditions similar to those from climate change are associated with significant changes in ADSCs and emphasizes the need for further research to understand their impact on health. |
| format | Article |
| id | doaj-art-5f86ec0052bc44ca882d84af61c973d7 |
| institution | OA Journals |
| issn | 2667-2782 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Climate Change and Health |
| spelling | doaj-art-5f86ec0052bc44ca882d84af61c973d72025-08-20T02:28:19ZengElsevierThe Journal of Climate Change and Health2667-27822025-03-012210036710.1016/j.joclim.2024.100367Impact of climate change on adipose-derived stem cells: A molecular and histological studySaeed Motesaddi Zarandi0Rasoul Yarahmadi1Rasul Nasiri2Mohammad Bayat3Hossein Nasiri4Abdollah Amini5Mohammad Esmaeil Motlagh6Hassan Rasoulzadeh7Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, IranAir Pollution Research Center, Department of Occupational Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, IranAir Pollution Research Center, Iran University of Medical Sciences, Tehran, Iran; Corresponding author at: Air Pollution Research Center, Iran University of Medical Sciences, Tehran, Iran.Price Institute of Surgical Research, University of Louisville, and Noveratech LLC, Louisville, Kentucky, USAFaculty of Geography, University of Tehran, Tehran, IranAssociate Professor of Biology and Anatomical Sciences Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pediatrics, School of Medicine, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, IranDepartment of Environmental Health Engineering, Maragheh of Medical Sciences, Tehran, IranBackground: Climate change, particularly temperature and humidity fluctuations, can affect biological systems. This study specifically investigates the impact of these two key aspects of climate change on adipose-derived stem cells (ADSCs) as a pilot study and starting point for further examinations into the biological effects of climate change-associated conditions. Methods: One-month-old male rats were kept for 4 months (equal to a 10-year climatic period) in 4 groups and exposed to conditions based on climatic data from Tehran's synoptic stations. Rats in the control group were exposed to conditions based on climatic data from 1991, and groups 2–4 were exposed to conditions based on climatic data from 1991 to 2000, 2001–2010, and 2011–2020, respectively. Monthly temperature, humidity, and day/night cycle averages were selected for animal exposure. After exposure, fat-derived stem cells were taken from each subject and assays assessing reactive oxygen species (ROS), cell viability and proliferation, and apoptosis were performed. Results: From 1991 to 2020, Tehran experienced an average temperature increase of 1.5 °C and a 15 % decrease in average humidity, conditions which when replicated in rodent models were associated with increased rates of ROS and caspase-3 expression, a reduction in Ki-67 antigen expression and in the duration of the life of cells, and an increase in the rate of apoptosis, such that apoptosis in ADSCs reached 25.51 %. Conclusion: The study demonstrates that environmental conditions similar to those from climate change are associated with significant changes in ADSCs and emphasizes the need for further research to understand their impact on health.http://www.sciencedirect.com/science/article/pii/S2667278224000701Climate changeHealth impactsAdipose-derived stem cells |
| spellingShingle | Saeed Motesaddi Zarandi Rasoul Yarahmadi Rasul Nasiri Mohammad Bayat Hossein Nasiri Abdollah Amini Mohammad Esmaeil Motlagh Hassan Rasoulzadeh Impact of climate change on adipose-derived stem cells: A molecular and histological study The Journal of Climate Change and Health Climate change Health impacts Adipose-derived stem cells |
| title | Impact of climate change on adipose-derived stem cells: A molecular and histological study |
| title_full | Impact of climate change on adipose-derived stem cells: A molecular and histological study |
| title_fullStr | Impact of climate change on adipose-derived stem cells: A molecular and histological study |
| title_full_unstemmed | Impact of climate change on adipose-derived stem cells: A molecular and histological study |
| title_short | Impact of climate change on adipose-derived stem cells: A molecular and histological study |
| title_sort | impact of climate change on adipose derived stem cells a molecular and histological study |
| topic | Climate change Health impacts Adipose-derived stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S2667278224000701 |
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