Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials
Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the therapeutic potentials of cutting-edge nanoparticles as demonstr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Nanotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2024.1479993/full |
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| author | Ranil Vikraman Kumarasamy Prabhu Manickam Natarajan Vidhya Rekha Umapathy Jeane Rebecca Roy Monica Mironescu Chella Perumal Palanisamy |
| author_facet | Ranil Vikraman Kumarasamy Prabhu Manickam Natarajan Vidhya Rekha Umapathy Jeane Rebecca Roy Monica Mironescu Chella Perumal Palanisamy |
| author_sort | Ranil Vikraman Kumarasamy |
| collection | DOAJ |
| description | Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the therapeutic potentials of cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches of major scientific databases, relevant studies published up to March 2024 were included, focusing on clinical trials utilizing advanced nanoparticles for therapeutic purposes. The review discusses the diverse applications of nanoparticles in oncology, infectious diseases, neurology, and other medical fields. Additionally, it scrutinizes the safety profiles, efficacy outcomes, and challenges associated with nanoparticle-based therapies. The findings underscore significant progress in translating nanoparticle research into clinical practice and highlight the potential of these innovative platforms to revolutionize medical treatments. This review contributes valuable insights into the growing field of nanoparticle-based therapeutics, fostering a deeper understanding of their clinical applications and implications in medical practice. |
| format | Article |
| id | doaj-art-5f826e7ac64b4ba98eb61a4cb27bf9db |
| institution | OA Journals |
| issn | 2673-3013 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj-art-5f826e7ac64b4ba98eb61a4cb27bf9db2025-08-20T01:50:45ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132024-10-01610.3389/fnano.2024.14799931479993Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trialsRanil Vikraman Kumarasamy0Prabhu Manickam Natarajan1Vidhya Rekha Umapathy2Jeane Rebecca Roy3Monica Mironescu4Chella Perumal Palanisamy5Department of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamil Nadu, IndiaDepartment of Clinical Sciences, Center of Medical and Bio-allied Health Sciences and Research, College of Dentistry, Ajman University, Ajman, United Arab EmiratesDepartment of Public Health Dentistry, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute, Chennai, Tamil Nadu, IndiaDepartment of Anatomy, Bhaarath Medical College and hospital, Bharath Institute of Higher Education and Research (BIHER), Chennai, Tamil Nadu, IndiaFaculty of Agricultural Sciences Food Industry and Environmental Protection, Lucian Blaga University of Sibiu, Sibiu, RomaniaDepartment of Chemical Technology, Faculty of Science, Chulalongkorn University, Bangkok, ThailandNanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the therapeutic potentials of cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches of major scientific databases, relevant studies published up to March 2024 were included, focusing on clinical trials utilizing advanced nanoparticles for therapeutic purposes. The review discusses the diverse applications of nanoparticles in oncology, infectious diseases, neurology, and other medical fields. Additionally, it scrutinizes the safety profiles, efficacy outcomes, and challenges associated with nanoparticle-based therapies. The findings underscore significant progress in translating nanoparticle research into clinical practice and highlight the potential of these innovative platforms to revolutionize medical treatments. This review contributes valuable insights into the growing field of nanoparticle-based therapeutics, fostering a deeper understanding of their clinical applications and implications in medical practice.https://www.frontiersin.org/articles/10.3389/fnano.2024.1479993/fullnanoparticlesnanomedicineclinical trialsdrug deliverytargeted therapy |
| spellingShingle | Ranil Vikraman Kumarasamy Prabhu Manickam Natarajan Vidhya Rekha Umapathy Jeane Rebecca Roy Monica Mironescu Chella Perumal Palanisamy Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials Frontiers in Nanotechnology nanoparticles nanomedicine clinical trials drug delivery targeted therapy |
| title | Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials |
| title_full | Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials |
| title_fullStr | Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials |
| title_full_unstemmed | Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials |
| title_short | Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials |
| title_sort | clinical applications and therapeutic potentials of advanced nanoparticles a comprehensive review on completed human clinical trials |
| topic | nanoparticles nanomedicine clinical trials drug delivery targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2024.1479993/full |
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