A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes
The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapo...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7814628 |
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| author | Gaurav Verma Aparna Dixit Craig S. Nunemaker |
| author_facet | Gaurav Verma Aparna Dixit Craig S. Nunemaker |
| author_sort | Gaurav Verma |
| collection | DOAJ |
| description | The role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential crosstalk between Ca2+ signaling and PHB function in pancreatic β-cells. Moreover, this review will focus on the effects of cytokines and glucolipotoxicity on Ca2+ signaling and its possible interaction with PHB. Improved understanding of this important mitochondrial protein may aid in the design of more targeted drugs to identify specific pathways involved with stress-induced dysfunction in the β-cell. |
| format | Article |
| id | doaj-art-5f6b02877dcb4cbfbfa99b0a2a6d69eb |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5f6b02877dcb4cbfbfa99b0a2a6d69eb2025-08-20T02:23:59ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/78146287814628A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and DiabetesGaurav Verma0Aparna Dixit1Craig S. Nunemaker2Molecular Metabolism, Lund University Diabetes Centre, Malmö -21428, SwedenSchool of Biotechnology, Jawaharlal Nehru University, -110067, New Delhi, IndiaHCOM-Biomedical Sciences, Ohio University, Athens Camp, US-45701 Ohio, USAThe role of mitochondria in apoptosis is well known; however, the mechanisms linking mitochondria to the proapoptotic effects of proinflammatory cytokines, hyperglycemia, and glucolipotoxicity are not completely understood. Complex Ca2+ signaling has emerged as a critical contributor to these proapoptotic effects and has gained significant attention in regulating the signaling processes of mitochondria. In pancreatic β-cells, Ca2+ plays an active role in β-cell function and survival. Prohibitin (PHB), a mitochondrial chaperone, is actively involved in maintaining the architecture of mitochondria. However, its possible interaction with Ca2+-activated signaling pathways has not been explored. The present review aims to examine potential crosstalk between Ca2+ signaling and PHB function in pancreatic β-cells. Moreover, this review will focus on the effects of cytokines and glucolipotoxicity on Ca2+ signaling and its possible interaction with PHB. Improved understanding of this important mitochondrial protein may aid in the design of more targeted drugs to identify specific pathways involved with stress-induced dysfunction in the β-cell.http://dx.doi.org/10.1155/2020/7814628 |
| spellingShingle | Gaurav Verma Aparna Dixit Craig S. Nunemaker A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes Journal of Diabetes Research |
| title | A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes |
| title_full | A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes |
| title_fullStr | A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes |
| title_full_unstemmed | A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes |
| title_short | A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes |
| title_sort | putative prohibitin calcium nexus in β cell mitochondria and diabetes |
| url | http://dx.doi.org/10.1155/2020/7814628 |
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