Genetic diversity and natural selection of Plasmodium falciparum Pf41 vaccine candidate in clinical isolates from Senegal

Genetic diversity and natural selection of Plasmodium falciparum Pf41 vaccine candidate in clinical isolates from Senegal

Abstract The merozoite surface antigen Pf41 was previously identified among the top 10 of new malaria vaccine candidates. Pf41 possesses red blood cell binding regions and conserved domains. We used population genetics approaches to determine the genetic diversity and to identify regions under balan...

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Main Authors: Rokhaya Sané, Babacar Souleymane Sambe, Aissatou Diagne, Joseph Faye, Fatoumata Diene Sarr, Serigne Ousmane Mbacké Diaw, Ibrahima Sarr, Arona Sabène Diatta, Hélène Ataume Mawounge Diatta, Papa Mbacké Sembène, Inès Vigan-Womas, Aissatou Toure-Balde, Faith Osier, Makhtar Niang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Plasmodium falciparum
Pf41
6-Cys
Genetic diversity
Natural selection
Vaccine candidate
Online Access:https://doi.org/10.1038/s41598-025-00784-y
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