Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery
Abstract Background This study aimed to assess the effect of oral melatonin consumption on improving heart function and reducing postoperative complications in patients undergoing coronary artery bypass grafting (CABG) surgery. Methods A total of 60 CABG patients in the postoperative period were inc...
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BMC
2025-07-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02789-9 |
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| author | Neshat Mohammadi Mehdi Alizadeh Samad Akbarzadeh Mikaeeil Rezaei Marzieh Mahmoodi Thomas Netticadan Ali Movahed |
| author_facet | Neshat Mohammadi Mehdi Alizadeh Samad Akbarzadeh Mikaeeil Rezaei Marzieh Mahmoodi Thomas Netticadan Ali Movahed |
| author_sort | Neshat Mohammadi |
| collection | DOAJ |
| description | Abstract Background This study aimed to assess the effect of oral melatonin consumption on improving heart function and reducing postoperative complications in patients undergoing coronary artery bypass grafting (CABG) surgery. Methods A total of 60 CABG patients in the postoperative period were included in this randomized, double-blind, placebo-controlled trial. The patients were divided into three groups: Group 1 (n = 20, 5 mg melatonin), Group 2 (n = 20, 10 mg melatonin), and the placebo group (n = 20). The patients were discharged about 8 to 10 days after the surgery. Blood samples were taken from all the patients before and after the intervention (for 60 days), and Biochemical parameters including creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), total antioxidant capacity (TAC), nitric oxide (NO) assessed. Echocardiography and the measurement of systolic and diastolic blood pressure were also performed on participants. Results Our results showed that melatonin treatment significantly increased the ejection fraction (%EF) and TAC levels in both the treatment groups compared to the placebo group (P < 0.05). Moreover, the levels of inflammatory and oxidative biomarkers, including TNF-α, MDA, and NO, decreased in the intervention group significantly (P < 0.05). In the placebo group, %EF decreased significantly (P = 0.042), while MDA increased (P < 0.001) and TAC decreased (P = 0.002). No significant changes were observed in LDH and CK-MB levels. The comparison of serum biomarkers between the two treatment groups showed that 10 mg of melatonin was more effective than 5 mg, but the difference was not significant (P > 0.05). Conclusion The present study showed that as a potential antioxidant, melatonin could alleviate oxidative stress and inflammation associated with CABG and is essential in improving overall heart function. Trial registration: IRCT20111119008129N14, first trial registration date: 01/08/2023. |
| format | Article |
| id | doaj-art-5f6799e52f154068b2920a64efd42ef8 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-5f6799e52f154068b2920a64efd42ef82025-08-20T04:01:53ZengBMCEuropean Journal of Medical Research2047-783X2025-07-0130111210.1186/s40001-025-02789-9Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgeryNeshat Mohammadi0Mehdi Alizadeh1Samad Akbarzadeh2Mikaeeil Rezaei3Marzieh Mahmoodi4Thomas Netticadan5Ali Movahed6Department of Clinical Biochemistry, Bushehr University of Medical SciencesDepartment of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical SciencesDepartment of Cardiovascular Surgery, Faculty of Medicine, Bushehr University of Medical SciencesDepartment of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical SciencesCanadian Centre for Agri-Food Research in Health and MedicineDepartment of Clinical Biochemistry, Faculty of Medicine, Bushehr University of Medical SciencesAbstract Background This study aimed to assess the effect of oral melatonin consumption on improving heart function and reducing postoperative complications in patients undergoing coronary artery bypass grafting (CABG) surgery. Methods A total of 60 CABG patients in the postoperative period were included in this randomized, double-blind, placebo-controlled trial. The patients were divided into three groups: Group 1 (n = 20, 5 mg melatonin), Group 2 (n = 20, 10 mg melatonin), and the placebo group (n = 20). The patients were discharged about 8 to 10 days after the surgery. Blood samples were taken from all the patients before and after the intervention (for 60 days), and Biochemical parameters including creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), total antioxidant capacity (TAC), nitric oxide (NO) assessed. Echocardiography and the measurement of systolic and diastolic blood pressure were also performed on participants. Results Our results showed that melatonin treatment significantly increased the ejection fraction (%EF) and TAC levels in both the treatment groups compared to the placebo group (P < 0.05). Moreover, the levels of inflammatory and oxidative biomarkers, including TNF-α, MDA, and NO, decreased in the intervention group significantly (P < 0.05). In the placebo group, %EF decreased significantly (P = 0.042), while MDA increased (P < 0.001) and TAC decreased (P = 0.002). No significant changes were observed in LDH and CK-MB levels. The comparison of serum biomarkers between the two treatment groups showed that 10 mg of melatonin was more effective than 5 mg, but the difference was not significant (P > 0.05). Conclusion The present study showed that as a potential antioxidant, melatonin could alleviate oxidative stress and inflammation associated with CABG and is essential in improving overall heart function. Trial registration: IRCT20111119008129N14, first trial registration date: 01/08/2023.https://doi.org/10.1186/s40001-025-02789-9AntioxidantCABGOxidative stressInflammationMelatonin |
| spellingShingle | Neshat Mohammadi Mehdi Alizadeh Samad Akbarzadeh Mikaeeil Rezaei Marzieh Mahmoodi Thomas Netticadan Ali Movahed Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery European Journal of Medical Research Antioxidant CABG Oxidative stress Inflammation Melatonin |
| title | Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery |
| title_full | Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery |
| title_fullStr | Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery |
| title_full_unstemmed | Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery |
| title_short | Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing CABG surgery |
| title_sort | melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart function in patients undergoing cabg surgery |
| topic | Antioxidant CABG Oxidative stress Inflammation Melatonin |
| url | https://doi.org/10.1186/s40001-025-02789-9 |
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