TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES
The ageing is the main risk factor for arterial hypertension (AH) and cardiovascular diseases. Natural ageing with normal BP is followed by changes in large arteries (rigidity), myocardium (hypertrophy) and diastolic relaxation and filling of cardiac muscle (diastolic dysfunstion). In AH these chang...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2014-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/104 |
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| author | J. D. Kobalava Yu. V. Kotovskaya |
| author_facet | J. D. Kobalava Yu. V. Kotovskaya |
| author_sort | J. D. Kobalava |
| collection | DOAJ |
| description | The ageing is the main risk factor for arterial hypertension (AH) and cardiovascular diseases. Natural ageing with normal BP is followed by changes in large arteries (rigidity), myocardium (hypertrophy) and diastolic relaxation and filling of cardiac muscle (diastolic dysfunstion). In AH these changes develop earlier and progress faster. These can be found at any age in AH. The telomere length (TL) — a special terminal structures on somatic cells chromosomes — is dependent on the age and is being shortened with age. This review concerns modern views on the role of telomeres as biological markers of ageing to understand the pathophysiology of essential arterial hypertension as a syndrome of accelerated cardiovascular system ageing. |
| format | Article |
| id | doaj-art-5f66876f71b4488cb4fc5f297b34b570 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2014-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-5f66876f71b4488cb4fc5f297b34b5702025-08-20T03:21:51Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-06-0106778410.15829/1560-4071-2014-6-77-84104TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVESJ. D. Kobalava0Yu. V. Kotovskaya1Peoples' Friendship University of Russia, Moscow, Russian Federation.Peoples' Friendship University of Russia, Moscow, Russian Federation.The ageing is the main risk factor for arterial hypertension (AH) and cardiovascular diseases. Natural ageing with normal BP is followed by changes in large arteries (rigidity), myocardium (hypertrophy) and diastolic relaxation and filling of cardiac muscle (diastolic dysfunstion). In AH these changes develop earlier and progress faster. These can be found at any age in AH. The telomere length (TL) — a special terminal structures on somatic cells chromosomes — is dependent on the age and is being shortened with age. This review concerns modern views on the role of telomeres as biological markers of ageing to understand the pathophysiology of essential arterial hypertension as a syndrome of accelerated cardiovascular system ageing.https://russjcardiol.elpub.ru/jour/article/view/104arterial hypertensiontelomeresaccelerated cardiovascular ageing |
| spellingShingle | J. D. Kobalava Yu. V. Kotovskaya TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES Российский кардиологический журнал arterial hypertension telomeres accelerated cardiovascular ageing |
| title | TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES |
| title_full | TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES |
| title_fullStr | TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES |
| title_full_unstemmed | TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES |
| title_short | TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES |
| title_sort | telomeres and arterial hypertension pathophysiology and clinical perspectives |
| topic | arterial hypertension telomeres accelerated cardiovascular ageing |
| url | https://russjcardiol.elpub.ru/jour/article/view/104 |
| work_keys_str_mv | AT jdkobalava telomeresandarterialhypertensionpathophysiologyandclinicalperspectives AT yuvkotovskaya telomeresandarterialhypertensionpathophysiologyandclinicalperspectives |