Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women
PurposeThe estimated glucose disposal rate (eGDR) is a noninvasive and practical marker for assessing insulin resistance, but its association with mortality in postmenopausal women remains uncertain.MethodsA cohort of 9371 postmenopausal women from the National Health and Nutrition Examination Surve...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1583991/full |
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| author | Han Qian Dayang Chai Shouming Zhao |
| author_facet | Han Qian Dayang Chai Shouming Zhao |
| author_sort | Han Qian |
| collection | DOAJ |
| description | PurposeThe estimated glucose disposal rate (eGDR) is a noninvasive and practical marker for assessing insulin resistance, but its association with mortality in postmenopausal women remains uncertain.MethodsA cohort of 9371 postmenopausal women from the National Health and Nutrition Examination Survey (1999-2018) was studied. Baseline eGDR was calculated, and mortality outcomes (all-cause and cardiovascular) were linked to National Death Index (NDI) records up to December 31, 2019. Multivariate Cox regression, restricted cubic splines, and subgroup analyses were employed to assess the relationships between eGDR and mortality.ResultsDuring a median follow-up of 98 months, 2151 deaths from all causes and 679 from cardiovascular causes were documented. In the multivariable-adjusted Cox model, higher eGDR quartiles were associated with progressively lower all-cause and cardiovascular mortality. In comparison to the lowest eGDR quartile, the highest quartile showed adjusted hazard ratios of 0.765 (0.646-0.906) for all-cause mortality and 0.677 (0.498-0.921) for cardiovascular mortality. A U-shaped relationship between eGDR and all-cause mortality was identified, with an inflection point at 5.11 mg/kg/min. Subgroup analyses revealed a stronger association between eGDR and all-cause as well as cardiovascular mortality in individuals younger than 60 years.ConclusionsAmong postmenopausal women, decreased eGDR, signifying higher insulin resistance, correlates with greater risks of all-cause and cardiovascular mortality. |
| format | Article |
| id | doaj-art-5f61b147f2f340c9881a41cce23e92e2 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-5f61b147f2f340c9881a41cce23e92e22025-08-20T03:34:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.15839911583991Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal womenHan QianDayang ChaiShouming ZhaoPurposeThe estimated glucose disposal rate (eGDR) is a noninvasive and practical marker for assessing insulin resistance, but its association with mortality in postmenopausal women remains uncertain.MethodsA cohort of 9371 postmenopausal women from the National Health and Nutrition Examination Survey (1999-2018) was studied. Baseline eGDR was calculated, and mortality outcomes (all-cause and cardiovascular) were linked to National Death Index (NDI) records up to December 31, 2019. Multivariate Cox regression, restricted cubic splines, and subgroup analyses were employed to assess the relationships between eGDR and mortality.ResultsDuring a median follow-up of 98 months, 2151 deaths from all causes and 679 from cardiovascular causes were documented. In the multivariable-adjusted Cox model, higher eGDR quartiles were associated with progressively lower all-cause and cardiovascular mortality. In comparison to the lowest eGDR quartile, the highest quartile showed adjusted hazard ratios of 0.765 (0.646-0.906) for all-cause mortality and 0.677 (0.498-0.921) for cardiovascular mortality. A U-shaped relationship between eGDR and all-cause mortality was identified, with an inflection point at 5.11 mg/kg/min. Subgroup analyses revealed a stronger association between eGDR and all-cause as well as cardiovascular mortality in individuals younger than 60 years.ConclusionsAmong postmenopausal women, decreased eGDR, signifying higher insulin resistance, correlates with greater risks of all-cause and cardiovascular mortality.https://www.frontiersin.org/articles/10.3389/fendo.2025.1583991/fullestimated glucose disposal rateinsulin resistanceall-cause mortalitycardiovascular mortalitypostmenopausal women |
| spellingShingle | Han Qian Dayang Chai Shouming Zhao Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women Frontiers in Endocrinology estimated glucose disposal rate insulin resistance all-cause mortality cardiovascular mortality postmenopausal women |
| title | Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women |
| title_full | Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women |
| title_fullStr | Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women |
| title_full_unstemmed | Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women |
| title_short | Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women |
| title_sort | insulin resistance assessed by estimated glucose disposal rate is associated with all cause and cardiovascular mortality among postmenopausal women |
| topic | estimated glucose disposal rate insulin resistance all-cause mortality cardiovascular mortality postmenopausal women |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1583991/full |
| work_keys_str_mv | AT hanqian insulinresistanceassessedbyestimatedglucosedisposalrateisassociatedwithallcauseandcardiovascularmortalityamongpostmenopausalwomen AT dayangchai insulinresistanceassessedbyestimatedglucosedisposalrateisassociatedwithallcauseandcardiovascularmortalityamongpostmenopausalwomen AT shoumingzhao insulinresistanceassessedbyestimatedglucosedisposalrateisassociatedwithallcauseandcardiovascularmortalityamongpostmenopausalwomen |