Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the Literature

We report a unique case of an adverse interaction between the oxazolidinone antibiotic linezolid, the tricyclic antidepressant amitriptyline and the opioid analgesic fentanyl in a 68-year-old woman with advanced ischemic peripheral arterial disease and sepsis, under empirical antibiotic treatment. W...

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Main Authors: Lampros Samartzis, Paraskevi Savvari, Sofoklis Kontogiannis, Stavros Dimopoulos
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Case Reports in Psychiatry
Online Access:http://dx.doi.org/10.1155/2013/617251
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author Lampros Samartzis
Paraskevi Savvari
Sofoklis Kontogiannis
Stavros Dimopoulos
author_facet Lampros Samartzis
Paraskevi Savvari
Sofoklis Kontogiannis
Stavros Dimopoulos
author_sort Lampros Samartzis
collection DOAJ
description We report a unique case of an adverse interaction between the oxazolidinone antibiotic linezolid, the tricyclic antidepressant amitriptyline and the opioid analgesic fentanyl in a 68-year-old woman with advanced ischemic peripheral arterial disease and sepsis, under empirical antibiotic treatment. We also summarize the current relevant literature as identified via PubMed, EMBASE, and PsycINFO as well as reference sections of selected articles.
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institution Kabale University
issn 2090-682X
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language English
publishDate 2013-01-01
publisher Wiley
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series Case Reports in Psychiatry
spelling doaj-art-5f5fe9d713874a369b7054104213fea42025-02-03T06:00:28ZengWileyCase Reports in Psychiatry2090-682X2090-68382013-01-01201310.1155/2013/617251617251Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the LiteratureLampros Samartzis0Paraskevi Savvari1Sofoklis Kontogiannis2Stavros Dimopoulos3Department of Psychiatry, Mental Health Services, Athalassa Psychiatric Hospital, 1452 Nicosia, CyprusDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, 80 Vas. Sofias Avenue, 11528 Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, 80 Vas. Sofias Avenue, 11528 Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, 80 Vas. Sofias Avenue, 11528 Athens, GreeceWe report a unique case of an adverse interaction between the oxazolidinone antibiotic linezolid, the tricyclic antidepressant amitriptyline and the opioid analgesic fentanyl in a 68-year-old woman with advanced ischemic peripheral arterial disease and sepsis, under empirical antibiotic treatment. We also summarize the current relevant literature as identified via PubMed, EMBASE, and PsycINFO as well as reference sections of selected articles.http://dx.doi.org/10.1155/2013/617251
spellingShingle Lampros Samartzis
Paraskevi Savvari
Sofoklis Kontogiannis
Stavros Dimopoulos
Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the Literature
Case Reports in Psychiatry
title Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the Literature
title_full Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the Literature
title_fullStr Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the Literature
title_full_unstemmed Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the Literature
title_short Linezolid Is Associated with Serotonin Syndrome in a Patient Receiving Amitriptyline, and Fentanyl: A Case Report and Review of the Literature
title_sort linezolid is associated with serotonin syndrome in a patient receiving amitriptyline and fentanyl a case report and review of the literature
url http://dx.doi.org/10.1155/2013/617251
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