Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval
Non-melanoma skin cancer (NMSC) is one of the most commonly diagnosed human malignancies and its incidence is steadily increasing. Locally advanced cutaneous squamous cell carcinoma of the extremities that is refractory to standard therapies can be challenging to treat, with amputation of the limb b...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1549683/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850279025454350336 |
|---|---|
| author | Danai-Dionysia Kanatoula Danai-Dionysia Kanatoula Danai-Dionysia Kanatoula Sebastian A. Wohlfeil Sebastian A. Wohlfeil Sebastian A. Wohlfeil Jens Jakob Peter Hohenberger Jochen Utikal Jochen Utikal Jochen Utikal |
| author_facet | Danai-Dionysia Kanatoula Danai-Dionysia Kanatoula Danai-Dionysia Kanatoula Sebastian A. Wohlfeil Sebastian A. Wohlfeil Sebastian A. Wohlfeil Jens Jakob Peter Hohenberger Jochen Utikal Jochen Utikal Jochen Utikal |
| author_sort | Danai-Dionysia Kanatoula |
| collection | DOAJ |
| description | Non-melanoma skin cancer (NMSC) is one of the most commonly diagnosed human malignancies and its incidence is steadily increasing. Locally advanced cutaneous squamous cell carcinoma of the extremities that is refractory to standard therapies can be challenging to treat, with amputation of the limb being the ultima ratio treatment. Here we present a 67-year-old female patient with metastatic SCC of the leg refractory to standard therapies who was effectively treated with isolated limb perfusion and is free of any sign of relapse since more than 3 years. This case report provides a brief review of the recent literature on isolated limb perfusion and how this effective treatment can preserve the patient’s quality of life by avoiding radical surgery and its negative consequences through limb salvage. |
| format | Article |
| id | doaj-art-5f5d2929240d4a5bac7f8ddbc643b838 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5f5d2929240d4a5bac7f8ddbc643b8382025-08-20T01:49:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15496831549683Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free intervalDanai-Dionysia Kanatoula0Danai-Dionysia Kanatoula1Danai-Dionysia Kanatoula2Sebastian A. Wohlfeil3Sebastian A. Wohlfeil4Sebastian A. Wohlfeil5Jens Jakob6Peter Hohenberger7Jochen Utikal8Jochen Utikal9Jochen Utikal10Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, GermanySkin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanySkin Cancer Unit, Dermato-Oncology, German Cancer Research Center (DKFZ) Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, GermanyDepartment of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, GermanySkin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanySkin Cancer Unit, Dermato-Oncology, German Cancer Research Center (DKFZ) Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, GermanyDivision of Surgical Oncology, Department of Surgery, Mannheim University Medical Center, University of Heidelberg, Mannheim, GermanyDivision of Surgical Oncology, Department of Surgery, Mannheim University Medical Center, University of Heidelberg, Mannheim, GermanyDepartment of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, GermanySkin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanySkin Cancer Unit, Dermato-Oncology, German Cancer Research Center (DKFZ) Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, GermanyNon-melanoma skin cancer (NMSC) is one of the most commonly diagnosed human malignancies and its incidence is steadily increasing. Locally advanced cutaneous squamous cell carcinoma of the extremities that is refractory to standard therapies can be challenging to treat, with amputation of the limb being the ultima ratio treatment. Here we present a 67-year-old female patient with metastatic SCC of the leg refractory to standard therapies who was effectively treated with isolated limb perfusion and is free of any sign of relapse since more than 3 years. This case report provides a brief review of the recent literature on isolated limb perfusion and how this effective treatment can preserve the patient’s quality of life by avoiding radical surgery and its negative consequences through limb salvage.https://www.frontiersin.org/articles/10.3389/fonc.2025.1549683/fullSCCsquamous cell carcinomatreatmentisolated limb perfusionrhTNFα |
| spellingShingle | Danai-Dionysia Kanatoula Danai-Dionysia Kanatoula Danai-Dionysia Kanatoula Sebastian A. Wohlfeil Sebastian A. Wohlfeil Sebastian A. Wohlfeil Jens Jakob Peter Hohenberger Jochen Utikal Jochen Utikal Jochen Utikal Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval Frontiers in Oncology SCC squamous cell carcinoma treatment isolated limb perfusion rhTNFα |
| title | Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval |
| title_full | Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval |
| title_fullStr | Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval |
| title_full_unstemmed | Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval |
| title_short | Effective treatment of refractory, locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion: a case report with unexpected long progression-free interval |
| title_sort | effective treatment of refractory locally metastatic squamous cell carcinoma of the leg with isolated limb perfusion a case report with unexpected long progression free interval |
| topic | SCC squamous cell carcinoma treatment isolated limb perfusion rhTNFα |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1549683/full |
| work_keys_str_mv | AT danaidionysiakanatoula effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT danaidionysiakanatoula effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT danaidionysiakanatoula effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT sebastianawohlfeil effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT sebastianawohlfeil effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT sebastianawohlfeil effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT jensjakob effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT peterhohenberger effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT jochenutikal effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT jochenutikal effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval AT jochenutikal effectivetreatmentofrefractorylocallymetastaticsquamouscellcarcinomaofthelegwithisolatedlimbperfusionacasereportwithunexpectedlongprogressionfreeinterval |