Multitarget CDK inhibitors roscovitine and UCN‑01 induce apoptosis in colorectal cancer cells by inhibiting cell cycle progression and transcription

Multitarget CDK inhibitors roscovitine and UCN‑01 induce apoptosis in colorectal cancer cells by inhibiting cell cycle progression and transcription

Abstract Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is steadily rising in developing nations. Cell cycle aberrations due to deregulation of cyclin dependent kinases (CDKs) and cyclins are common events during colorectal carcinogenesis. Herein,...

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Bibliographic Details
Main Authors: Sonal Mohan Manohar, Kalpana Sanjay Joshi
Format: Article
Language:English
Published: Universidade de São Paulo 2025-01-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
CDK inhibitors
Roscovitine
UCN-01
Colorectal cancer
Cell cycle
Apoptosis
Transcription inhibition
Drug combination
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100333&lng=en&tlng=en
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