Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis
Background: non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Interna Publishing
2017-08-01
|
| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | https://www.actamedindones.org/index.php/ijim/article/view/381 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849303913758457856 |
|---|---|
| author | Guntur Darmawan Laniyati Hamijoyo Irsan Hasan |
| author_facet | Guntur Darmawan Laniyati Hamijoyo Irsan Hasan |
| author_sort | Guntur Darmawan |
| collection | DOAJ |
| description | Background: non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD. Methods: a systematic literature review was conducted using Pubmed and Cochrane library. The quality of all studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). All data were analyzed using REVIEW MANAGER 5.3. Results: eleven studies from America and Asia involving 100,275 subjects were included. The pooled adjusted OR for NAFLD was 1.92 (95% CI: 1.66-2.23; p<0.00001). Subgroup analyses were done based on study design, gender, non-diabetic subjects, non-obese subjects. All subgroup analyses showed statistically significant adjusted OR and most of which having low to moderate heterogeneity. Two studies revealed relationship between increased serum uric acid levels and severity of NAFLD. No publication bias was observed. Conclusion: our study demonstrated association between serum uric acid level and NAFLD. This finding brings a new insight of uric acid in clinical practice. Increased in serum uric acid levels might serve as a trigger for physician to screen for NAFLD. |
| format | Article |
| id | doaj-art-5f5bb2dd30ff4f31aee50cc7cb25f6b1 |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-5f5bb2dd30ff4f31aee50cc7cb25f6b12025-08-20T03:55:54ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322017-08-01492201Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-AnalysisGuntur Darmawan0Laniyati Hamijoyo1Irsan Hasan2Department of Internal Medicine, Faculty of Medicine, Padjadjaran University-Hasan Sadikin Hospital, Bandung, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Padjadjaran University-Hasan Sadikin Hospital, Bandung, IndonesiaDivision of Hepatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, IndonesiaBackground: non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD. Methods: a systematic literature review was conducted using Pubmed and Cochrane library. The quality of all studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). All data were analyzed using REVIEW MANAGER 5.3. Results: eleven studies from America and Asia involving 100,275 subjects were included. The pooled adjusted OR for NAFLD was 1.92 (95% CI: 1.66-2.23; p<0.00001). Subgroup analyses were done based on study design, gender, non-diabetic subjects, non-obese subjects. All subgroup analyses showed statistically significant adjusted OR and most of which having low to moderate heterogeneity. Two studies revealed relationship between increased serum uric acid levels and severity of NAFLD. No publication bias was observed. Conclusion: our study demonstrated association between serum uric acid level and NAFLD. This finding brings a new insight of uric acid in clinical practice. Increased in serum uric acid levels might serve as a trigger for physician to screen for NAFLD.https://www.actamedindones.org/index.php/ijim/article/view/381uric acidnon-alcoholic fatty liver diseasemeta-analysis |
| spellingShingle | Guntur Darmawan Laniyati Hamijoyo Irsan Hasan Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis Acta Medica Indonesiana uric acid non-alcoholic fatty liver disease meta-analysis |
| title | Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis |
| title_full | Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis |
| title_fullStr | Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis |
| title_full_unstemmed | Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis |
| title_short | Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis |
| title_sort | association between serum uric acid and non alcoholic fatty liver disease a meta analysis |
| topic | uric acid non-alcoholic fatty liver disease meta-analysis |
| url | https://www.actamedindones.org/index.php/ijim/article/view/381 |
| work_keys_str_mv | AT gunturdarmawan associationbetweenserumuricacidandnonalcoholicfattyliverdiseaseametaanalysis AT laniyatihamijoyo associationbetweenserumuricacidandnonalcoholicfattyliverdiseaseametaanalysis AT irsanhasan associationbetweenserumuricacidandnonalcoholicfattyliverdiseaseametaanalysis |