The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course
PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in i...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/349469 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545784219828224 |
|---|---|
| author | Jessica Mwinyi Christa Grete-Wenger Jyrki J. Eloranta Gerd A. Kullak-Ublick |
| author_facet | Jessica Mwinyi Christa Grete-Wenger Jyrki J. Eloranta Gerd A. Kullak-Ublick |
| author_sort | Jessica Mwinyi |
| collection | DOAJ |
| description | PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls. We determined genetic variants in the coding exons and flanking intronic sequences of the NR1C3 gene in 284 IBD patients and 194 controls and predicted NR1C3 haplotypes via bioinformatic analysis. We investigated whether certain NR1C3 variants are associated with susceptibility to IBD or its disease course. None of the detected 22 NR1C3 variants were associated with IBD. Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses. None of the NR3C1 haplotypes showed association with IBD development or disease course. We conclude that NR1C3 haplotypes are not related to IBD susceptibility or IBD disease activity. |
| format | Article |
| id | doaj-art-5f5713a252e7481b9ccd7e211020c13f |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-5f5713a252e7481b9ccd7e211020c13f2025-02-03T07:24:44ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/349469349469The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease CourseJessica Mwinyi0Christa Grete-Wenger1Jyrki J. Eloranta2Gerd A. Kullak-Ublick3Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, SwitzerlandDepartment of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, SwitzerlandDepartment of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, SwitzerlandDepartment of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, SwitzerlandPPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls. We determined genetic variants in the coding exons and flanking intronic sequences of the NR1C3 gene in 284 IBD patients and 194 controls and predicted NR1C3 haplotypes via bioinformatic analysis. We investigated whether certain NR1C3 variants are associated with susceptibility to IBD or its disease course. None of the detected 22 NR1C3 variants were associated with IBD. Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses. None of the NR3C1 haplotypes showed association with IBD development or disease course. We conclude that NR1C3 haplotypes are not related to IBD susceptibility or IBD disease activity.http://dx.doi.org/10.1155/2012/349469 |
| spellingShingle | Jessica Mwinyi Christa Grete-Wenger Jyrki J. Eloranta Gerd A. Kullak-Ublick The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course PPAR Research |
| title | The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course |
| title_full | The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course |
| title_fullStr | The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course |
| title_full_unstemmed | The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course |
| title_short | The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course |
| title_sort | impact of pparγ genetic variants on ibd susceptibility and ibd disease course |
| url | http://dx.doi.org/10.1155/2012/349469 |
| work_keys_str_mv | AT jessicamwinyi theimpactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse AT christagretewenger theimpactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse AT jyrkijeloranta theimpactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse AT gerdakullakublick theimpactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse AT jessicamwinyi impactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse AT christagretewenger impactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse AT jyrkijeloranta impactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse AT gerdakullakublick impactofpparggeneticvariantsonibdsusceptibilityandibddiseasecourse |