Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease
Objective: The aim of this study was to investigate the correlation between dopamine transporter (DAT) positron emission tomography (PET)/computed tomography (CT) and the clinical characteristics and rating scales of Parkinson’s disease (PD) patients. Additionally, we sought to as...
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IMR Press
2025-04-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/24/4/10.31083/JIN24440 |
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| author | Xiaodong Wu Ziyuan Li Jing Gan Feng Wei Ping Wu Sheng Liang Yufei Ma Lin Ding Chuantao Zuo Zhenguo Liu Hui Wang Yafu Yin |
| author_facet | Xiaodong Wu Ziyuan Li Jing Gan Feng Wei Ping Wu Sheng Liang Yufei Ma Lin Ding Chuantao Zuo Zhenguo Liu Hui Wang Yafu Yin |
| author_sort | Xiaodong Wu |
| collection | DOAJ |
| description | Objective: The aim of this study was to investigate the correlation between dopamine transporter (DAT) positron emission tomography (PET)/computed tomography (CT) and the clinical characteristics and rating scales of Parkinson’s disease (PD) patients. Additionally, we sought to assess the scientific validity and feasibility of integrating 3D-dopaminergic binding parameters into the clinical scoring system for PD. Methods: A total of 75 patients with PD who underwent 11C-methyl-N-2β-methyl ester-3β-(4-fluorophenyl) tropane (11C-CFT) PET/CT from April, 2019 to June, 2021 were retrospectively analyzed. Clinical characteristics, including age, sex, and disease duration, as well as the modified Hoehn-Yahr (H-Y) scale, Unified Parkinson’s Disease Rating Scale (UPDRS) parts II and III (II-III), and Mini-Mental State Examination (MMSE) scores of PD patients during the corresponding time periods were collected. DAT binding parameters and their derived parameters based on plane and 3D images in the neostriatum were analyzed for consistency with plane and 3D parameters, and the correlation between DAT parameters and the clinical features of patients were assessed using SPSS software. Results: The DAT binding parameters derived from 3D images demonstrated good consistency with the plane parameters (p < 0.05). The asymmetry index (ai) of DAT binding parameters based on 3D and plane images showed good consistency in the anterior putamen (p < 0.05). The plane parameters of the anterior and posterior putamen were statistically correlated with the UPDRS II-III score and H-Y score of PD patients (p < 0.05), whereas those of the caudate nucleus were correlated with UPDRS II and MMSE scores. The 3D parameters in the neostriatum showed good statistical correlation with disease duration, UPDRS II-III score, H-Y score, and H-Y stage of PD patients (p < 0.05), and the ai was significantly correlated with MMSE score (p < 0.05). The 3D parameters in the putamen and posterior putamen exhibited significant statistical correlation with the UPDRS II-III score, H-Y score, and H-Y stage in PD patients (p < 0.05). The ai in the putamen showed statistical correlation with UPDRS III and MMSE scores, and the ai in the posterior putamen showed statistical correlation with UPDRS II score (p < 0.05). Conclusions: Quantitative parameters based on plane and 3D images of 11C-CFT PET/CT showed good consistency. Moreover, 3D parameters in the neostriatum had a stronger correlation with activities of daily living, UPDRS motor scores, disease severity and duration, and cognition compared with plane parameters in PD patients. |
| format | Article |
| id | doaj-art-5f541ab67982446c820614cf9e6e83fb |
| institution | OA Journals |
| issn | 0219-6352 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-5f541ab67982446c820614cf9e6e83fb2025-08-20T02:20:13ZengIMR PressJournal of Integrative Neuroscience0219-63522025-04-012442444010.31083/JIN24440S0219-6352(24)00904-5Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s DiseaseXiaodong Wu0Ziyuan Li1Jing Gan2Feng Wei3Ping Wu4Sheng Liang5Yufei Ma6Lin Ding7Chuantao Zuo8Zhenguo Liu9Hui Wang10Yafu Yin11Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaPET Center, Hua Shan Hospital, Fudan University, 200040 Shanghai, ChinaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaPET Center, Hua Shan Hospital, Fudan University, 200040 Shanghai, ChinaDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaDepartment of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, ChinaObjective: The aim of this study was to investigate the correlation between dopamine transporter (DAT) positron emission tomography (PET)/computed tomography (CT) and the clinical characteristics and rating scales of Parkinson’s disease (PD) patients. Additionally, we sought to assess the scientific validity and feasibility of integrating 3D-dopaminergic binding parameters into the clinical scoring system for PD. Methods: A total of 75 patients with PD who underwent 11C-methyl-N-2β-methyl ester-3β-(4-fluorophenyl) tropane (11C-CFT) PET/CT from April, 2019 to June, 2021 were retrospectively analyzed. Clinical characteristics, including age, sex, and disease duration, as well as the modified Hoehn-Yahr (H-Y) scale, Unified Parkinson’s Disease Rating Scale (UPDRS) parts II and III (II-III), and Mini-Mental State Examination (MMSE) scores of PD patients during the corresponding time periods were collected. DAT binding parameters and their derived parameters based on plane and 3D images in the neostriatum were analyzed for consistency with plane and 3D parameters, and the correlation between DAT parameters and the clinical features of patients were assessed using SPSS software. Results: The DAT binding parameters derived from 3D images demonstrated good consistency with the plane parameters (p < 0.05). The asymmetry index (ai) of DAT binding parameters based on 3D and plane images showed good consistency in the anterior putamen (p < 0.05). The plane parameters of the anterior and posterior putamen were statistically correlated with the UPDRS II-III score and H-Y score of PD patients (p < 0.05), whereas those of the caudate nucleus were correlated with UPDRS II and MMSE scores. The 3D parameters in the neostriatum showed good statistical correlation with disease duration, UPDRS II-III score, H-Y score, and H-Y stage of PD patients (p < 0.05), and the ai was significantly correlated with MMSE score (p < 0.05). The 3D parameters in the putamen and posterior putamen exhibited significant statistical correlation with the UPDRS II-III score, H-Y score, and H-Y stage in PD patients (p < 0.05). The ai in the putamen showed statistical correlation with UPDRS III and MMSE scores, and the ai in the posterior putamen showed statistical correlation with UPDRS II score (p < 0.05). Conclusions: Quantitative parameters based on plane and 3D images of 11C-CFT PET/CT showed good consistency. Moreover, 3D parameters in the neostriatum had a stronger correlation with activities of daily living, UPDRS motor scores, disease severity and duration, and cognition compared with plane parameters in PD patients.https://www.imrpress.com/journal/JIN/24/4/10.31083/JIN24440parkinson’s disease11c-cftpet/ctplane parameter3d parameter |
| spellingShingle | Xiaodong Wu Ziyuan Li Jing Gan Feng Wei Ping Wu Sheng Liang Yufei Ma Lin Ding Chuantao Zuo Zhenguo Liu Hui Wang Yafu Yin Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease Journal of Integrative Neuroscience parkinson’s disease 11c-cft pet/ct plane parameter 3d parameter |
| title | Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease |
| title_full | Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease |
| title_fullStr | Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease |
| title_full_unstemmed | Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease |
| title_short | Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease |
| title_sort | correlation analysis between 3d and plane dat binding parameters of 11c cft pet ct and the clinical characteristics of patients with parkinson s disease |
| topic | parkinson’s disease 11c-cft pet/ct plane parameter 3d parameter |
| url | https://www.imrpress.com/journal/JIN/24/4/10.31083/JIN24440 |
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