A pilot study investigating the effect of pembrolizumab on the tumoral immunoprofile of newly diagnosed mullerian cancers

A pilot study investigating the effect of pembrolizumab on the tumoral immunoprofile of newly diagnosed mullerian cancers

Objective: This pilot window of opportunity study was conducted to assess feasibility, toxicity, and changes in immune parameters in response to one dose of the PD-1 inhibitor, pembrolizumab, in patients newly diagnosed with mullerian epithelial cancers. Methods: Eligible patients received pembroliz...

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Bibliographic Details
Main Authors: Stéphanie L. Gaillard, Gloria Broadwater, Andrew Berchuck, William S. Andrews, Laura J. Havrilesky, Brittany A. Davidson, Rebecca A. Previs, Mark D. Starr, John S. Yi, Andrew B. Nixon, Jadee L. Neff, Jose Ramon Conejo-Garcia, Angeles Alvarez Secord
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Gynecologic Oncology Reports
Subjects:
Pembrolizumab
Ovarian cancer
Endometrial cancer
PD-L1
Tumor immune microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2352578925000955
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