Programmable protein stabilization with language model-derived peptide guides

Programmable protein stabilization with language model-derived peptide guides

Abstract Dysregulated protein degradation via the ubiquitin-proteasomal pathway can induce numerous disease phenotypes, including cancer, neurodegeneration, and diabetes. While small molecule-based targeted protein degradation (TPD) and targeted protein stabilization (TPS) platforms can address this...

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Main Authors: Lauren Hong, Tianzheng Ye, Tian Z. Wang, Divya Srijay, Howard Liu, Lin Zhao, Rio Watson, Sophia Vincoff, Tianlai Chen, Kseniia Kholina, Shrey Goel, Matthew P. DeLisa, Pranam Chatterjee
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58872-6
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