DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

Abstract DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vecto...

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Main Authors: Yiling Yang, Ruoke Wang, Fenglin Guo, Tian Zhao, Yuqing Lei, Qianqian Yang, Yige Zeng, Ziqing Yang, Tatchapon Ajavavarakula, Ruijie Tan, Mingxi Li, Haodi Dong, Mengyue Niu, Keyan Bao, Hao Geng, Qining Lv, Qi Zhang, Xuanling Shi, Peng Liu, Jiwan Ge, Xinquan Wang, Linqi Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01059-9
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