Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged Hospitalization
While the impact of air pollution on acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has been widely studied, its effect on hospitalization outcomes remains less explored. This study examines the influence of short-term air pollution exposure on adverse hospitalization outcomes...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2073-4433/16/1/36 |
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| author | Jovan Javorac Dejan Živanović Miroslav Ilić Ana Milenković Emilija Vujičić Dragica Kovačević Jelena Zvekić-Svorcan Darko Mikić Svetlana Stojkov Jasminka Bačevac Eminović Marija Jevtić |
| author_facet | Jovan Javorac Dejan Živanović Miroslav Ilić Ana Milenković Emilija Vujičić Dragica Kovačević Jelena Zvekić-Svorcan Darko Mikić Svetlana Stojkov Jasminka Bačevac Eminović Marija Jevtić |
| author_sort | Jovan Javorac |
| collection | DOAJ |
| description | While the impact of air pollution on acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has been widely studied, its effect on hospitalization outcomes remains less explored. This study examines the influence of short-term air pollution exposure on adverse hospitalization outcomes—mortality, mechanical ventilation use, and prolonged hospitalization—in patients with non-infectious severe AECOPD in Novi Sad, Serbia. Using a five-year time-series analysis, concentrations of selected air pollutants (PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2</sub>, and NO<sub>2</sub>) and meteorological data were integrated with hospitalization outcomes. Distributed lag non-linear models (DLNMs) revealed significant associations between rising air pollutant levels and some unfavorable outcomes. Exposure to rising PM<sub>2.5</sub> (urban background) and SO<sub>2</sub> (urban traffic) concentrations were linked to higher risks of mechanical ventilation (cumulative OR 21.95 (95% CI 1.07–449.45) and 11.37 (95% CI 1.25–103.27), respectively) and prolonged non-infectious AECOPD hospitalization (cumulative RR 2.27 (95% CI 1.14–4.52) and 2.24 (95% CI 1.38–3.64), respectively). No cumulative lag effects on mortality were observed, though specific patterns emerged in individual lag models. These findings highlight the critical role of improving air quality in reducing some COPD-related hospitalization risks. |
| format | Article |
| id | doaj-art-5f40fa0e0553436ab9734c779d6ac060 |
| institution | Kabale University |
| issn | 2073-4433 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Atmosphere |
| spelling | doaj-art-5f40fa0e0553436ab9734c779d6ac0602025-01-24T13:21:47ZengMDPI AGAtmosphere2073-44332025-01-011613610.3390/atmos16010036Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged HospitalizationJovan Javorac0Dejan Živanović1Miroslav Ilić2Ana Milenković3Emilija Vujičić4Dragica Kovačević5Jelena Zvekić-Svorcan6Darko Mikić7Svetlana Stojkov8Jasminka Bačevac Eminović9Marija Jevtić10Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaInstitute for Pulmonary Diseases of Vojvodina, 21204 Sremska Kamenica, SerbiaInstitute for Pulmonary Diseases of Vojvodina, 21204 Sremska Kamenica, SerbiaFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaMedical Faculty of the Military Medical Academy, University of Defence, 11000 Belgrade, SerbiaDepartment of Biomedical Sciences, College of Vocational Studies for the Education of Preschool Teachers and Sports Trainers, 24000 Subotica, SerbiaHealth Center “Tutin”, 36320 Tutin, SerbiaFaculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaWhile the impact of air pollution on acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has been widely studied, its effect on hospitalization outcomes remains less explored. This study examines the influence of short-term air pollution exposure on adverse hospitalization outcomes—mortality, mechanical ventilation use, and prolonged hospitalization—in patients with non-infectious severe AECOPD in Novi Sad, Serbia. Using a five-year time-series analysis, concentrations of selected air pollutants (PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2</sub>, and NO<sub>2</sub>) and meteorological data were integrated with hospitalization outcomes. Distributed lag non-linear models (DLNMs) revealed significant associations between rising air pollutant levels and some unfavorable outcomes. Exposure to rising PM<sub>2.5</sub> (urban background) and SO<sub>2</sub> (urban traffic) concentrations were linked to higher risks of mechanical ventilation (cumulative OR 21.95 (95% CI 1.07–449.45) and 11.37 (95% CI 1.25–103.27), respectively) and prolonged non-infectious AECOPD hospitalization (cumulative RR 2.27 (95% CI 1.14–4.52) and 2.24 (95% CI 1.38–3.64), respectively). No cumulative lag effects on mortality were observed, though specific patterns emerged in individual lag models. These findings highlight the critical role of improving air quality in reducing some COPD-related hospitalization risks.https://www.mdpi.com/2073-4433/16/1/36acute exacerbations of chronic obstructive pulmonary diseaseCOPDair pollutionmortalitymechanical ventilationhospitalization duration |
| spellingShingle | Jovan Javorac Dejan Živanović Miroslav Ilić Ana Milenković Emilija Vujičić Dragica Kovačević Jelena Zvekić-Svorcan Darko Mikić Svetlana Stojkov Jasminka Bačevac Eminović Marija Jevtić Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged Hospitalization Atmosphere acute exacerbations of chronic obstructive pulmonary disease COPD air pollution mortality mechanical ventilation hospitalization duration |
| title | Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged Hospitalization |
| title_full | Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged Hospitalization |
| title_fullStr | Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged Hospitalization |
| title_full_unstemmed | Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged Hospitalization |
| title_short | Air Pollution and COPD: Unveiling Hidden Risks of Mortality, Mechanical Ventilation, and Prolonged Hospitalization |
| title_sort | air pollution and copd unveiling hidden risks of mortality mechanical ventilation and prolonged hospitalization |
| topic | acute exacerbations of chronic obstructive pulmonary disease COPD air pollution mortality mechanical ventilation hospitalization duration |
| url | https://www.mdpi.com/2073-4433/16/1/36 |
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