Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer.
<h4>Background</h4>Metabolic syndrome and/or its components have been demonstrated to be risk factors for several cancers. They are also found to influence survival in breast, colon and prostate cancer, but the prognostic value of metabolic syndrome in gastric cancer has not been investi...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089965&type=printable |
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| author | Xiao-li Wei Miao-zhen Qiu Huan-xin Lin Ying Zhang Jian-xin Liu Hong-mei Yu Wei-ping Liang Ying Jin Chao Ren Ming-ming He Wei-wei Chen Hui-yan Luo Zhi-qiang Wang Dong-sheng Zhang Feng-hua Wang Yu-hong Li Rui-hua Xu |
| author_facet | Xiao-li Wei Miao-zhen Qiu Huan-xin Lin Ying Zhang Jian-xin Liu Hong-mei Yu Wei-ping Liang Ying Jin Chao Ren Ming-ming He Wei-wei Chen Hui-yan Luo Zhi-qiang Wang Dong-sheng Zhang Feng-hua Wang Yu-hong Li Rui-hua Xu |
| author_sort | Xiao-li Wei |
| collection | DOAJ |
| description | <h4>Background</h4>Metabolic syndrome and/or its components have been demonstrated to be risk factors for several cancers. They are also found to influence survival in breast, colon and prostate cancer, but the prognostic value of metabolic syndrome in gastric cancer has not been investigated.<h4>Methods</h4>Clinical data and pre-treatment information of metabolic syndrome of 587 patients diagnosed with early stage gastric cancer were retrospectively collected. The associations of metabolic syndrome and/or its components with clinical characteristics and overall survival in early stage gastric cancer were analyzed.<h4>Results</h4>Metabolic syndrome was identified to be associated with a higher tumor cell differentiation (P=0.036). Metabolic syndrome was also demonstrated to be a significant and independent predictor for better survival in patients aged >50 years old (P=0.009 in multivariate analysis) or patients with proximal gastric cancer (P=0.047 in multivariate analysis). No association was found between single metabolic syndrome component and overall survival in early stage gastric cancer. In addition, patients with hypertension might have a trend of better survival through a good control of blood pressure (P=0.052 in univariate analysis).<h4>Conclusions</h4>Metabolic syndrome was associated with a better tumor cell differentiation in patients with early stage gastric cancer. Moreover, metabolic syndrome was a significant and independent predictor for better survival in patients with old age or proximal tumors. |
| format | Article |
| id | doaj-art-5f3cc11bd6be4252bba2d31021a4ebce |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5f3cc11bd6be4252bba2d31021a4ebce2025-08-20T03:11:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e8996510.1371/journal.pone.0089965Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer.Xiao-li WeiMiao-zhen QiuHuan-xin LinYing ZhangJian-xin LiuHong-mei YuWei-ping LiangYing JinChao RenMing-ming HeWei-wei ChenHui-yan LuoZhi-qiang WangDong-sheng ZhangFeng-hua WangYu-hong LiRui-hua Xu<h4>Background</h4>Metabolic syndrome and/or its components have been demonstrated to be risk factors for several cancers. They are also found to influence survival in breast, colon and prostate cancer, but the prognostic value of metabolic syndrome in gastric cancer has not been investigated.<h4>Methods</h4>Clinical data and pre-treatment information of metabolic syndrome of 587 patients diagnosed with early stage gastric cancer were retrospectively collected. The associations of metabolic syndrome and/or its components with clinical characteristics and overall survival in early stage gastric cancer were analyzed.<h4>Results</h4>Metabolic syndrome was identified to be associated with a higher tumor cell differentiation (P=0.036). Metabolic syndrome was also demonstrated to be a significant and independent predictor for better survival in patients aged >50 years old (P=0.009 in multivariate analysis) or patients with proximal gastric cancer (P=0.047 in multivariate analysis). No association was found between single metabolic syndrome component and overall survival in early stage gastric cancer. In addition, patients with hypertension might have a trend of better survival through a good control of blood pressure (P=0.052 in univariate analysis).<h4>Conclusions</h4>Metabolic syndrome was associated with a better tumor cell differentiation in patients with early stage gastric cancer. Moreover, metabolic syndrome was a significant and independent predictor for better survival in patients with old age or proximal tumors.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089965&type=printable |
| spellingShingle | Xiao-li Wei Miao-zhen Qiu Huan-xin Lin Ying Zhang Jian-xin Liu Hong-mei Yu Wei-ping Liang Ying Jin Chao Ren Ming-ming He Wei-wei Chen Hui-yan Luo Zhi-qiang Wang Dong-sheng Zhang Feng-hua Wang Yu-hong Li Rui-hua Xu Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer. PLoS ONE |
| title | Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer. |
| title_full | Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer. |
| title_fullStr | Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer. |
| title_full_unstemmed | Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer. |
| title_short | Patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer. |
| title_sort | patients with old age or proximal tumors benefit from metabolic syndrome in early stage gastric cancer |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089965&type=printable |
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