Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients
Introduction: Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage, or metabolic insult. Senescence is associated with ageing and chronic age associated diseases such as cardiovascular disease and diabetes. The involvement of cellular senescence in acut...
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MDPI AG
2024-09-01
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| author | Sean McCallion Thomas McLarnon Eamonn Cooper Andrew R. English Steven Watterson Melody El Chemaly Cathy McGeough Amanda Eakin Tan Ahmed Philip Gardiner Adrian Pendleton Gary Wright Declan McGuigan Maurice O’Kane Aaron Peace Ying Kuan David S. Gibson Paula L. McClean Catriona Kelly Victoria McGilligan Elaine K. Murray Frank McCarroll Anthony J. Bjourson Taranjit Singh Rai |
| author_facet | Sean McCallion Thomas McLarnon Eamonn Cooper Andrew R. English Steven Watterson Melody El Chemaly Cathy McGeough Amanda Eakin Tan Ahmed Philip Gardiner Adrian Pendleton Gary Wright Declan McGuigan Maurice O’Kane Aaron Peace Ying Kuan David S. Gibson Paula L. McClean Catriona Kelly Victoria McGilligan Elaine K. Murray Frank McCarroll Anthony J. Bjourson Taranjit Singh Rai |
| author_sort | Sean McCallion |
| collection | DOAJ |
| description | Introduction: Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage, or metabolic insult. Senescence is associated with ageing and chronic age associated diseases such as cardiovascular disease and diabetes. The involvement of cellular senescence in acute kidney injury (AKI) and chronic kidney disease (CKD) is not fully understood. However, recent studies suggest that such patients have a higher-than-normal level of cellular senescence and accelerated ageing. Methods: This study aimed to discover key biomarkers of senescence in AKI and CKD patients compared to other chronic ageing diseases in controls using OLINK proteomics. Results: We show that senescence proteins CKAP4 (<i>p</i>-value < 0.0001) and PTX3 (<i>p</i>-value < 0.0001) are upregulated in AKI and CKD patients compared with controls with chronic diseases, suggesting the proteins may play a role in overall kidney disease development. Conclusions: CKAP4 was found to be differentially expressed in both AKI and CKD when compared to UHCs; hence, this biomarker could be a prognostic senescence biomarker of both AKI and CKD. |
| format | Article |
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| issn | 2073-4409 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-5f393bfa169e4c3a8f6b91c17a4e05b62025-08-20T01:47:42ZengMDPI AGCells2073-44092024-09-011319161310.3390/cells13191613Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease PatientsSean McCallion0Thomas McLarnon1Eamonn Cooper2Andrew R. English3Steven Watterson4Melody El Chemaly5Cathy McGeough6Amanda Eakin7Tan Ahmed8Philip Gardiner9Adrian Pendleton10Gary Wright11Declan McGuigan12Maurice O’Kane13Aaron Peace14Ying Kuan15David S. Gibson16Paula L. McClean17Catriona Kelly18Victoria McGilligan19Elaine K. Murray20Frank McCarroll21Anthony J. Bjourson22Taranjit Singh Rai23Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKWestern Health and Social Care Trust (WHSCT), Altnagelvin Area Hospital, Londonderry BT47 6SB, UKBelfast Health and Social Care Trust (BHSCT), Belfast City Hospital, Belfast BT9 7AB, UKBelfast Health and Social Care Trust (BHSCT), Belfast City Hospital, Belfast BT9 7AB, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKWestern Health and Social Care Trust (WHSCT), Altnagelvin Area Hospital, Londonderry BT47 6SB, UKWestern Health and Social Care Trust (WHSCT), Altnagelvin Area Hospital, Londonderry BT47 6SB, UKWestern Health and Social Care Trust (WHSCT), Altnagelvin Area Hospital, Londonderry BT47 6SB, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKWestern Health and Social Care Trust (WHSCT), Altnagelvin Area Hospital, Londonderry BT47 6SB, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT48 7JL, UKIntroduction: Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage, or metabolic insult. Senescence is associated with ageing and chronic age associated diseases such as cardiovascular disease and diabetes. The involvement of cellular senescence in acute kidney injury (AKI) and chronic kidney disease (CKD) is not fully understood. However, recent studies suggest that such patients have a higher-than-normal level of cellular senescence and accelerated ageing. Methods: This study aimed to discover key biomarkers of senescence in AKI and CKD patients compared to other chronic ageing diseases in controls using OLINK proteomics. Results: We show that senescence proteins CKAP4 (<i>p</i>-value < 0.0001) and PTX3 (<i>p</i>-value < 0.0001) are upregulated in AKI and CKD patients compared with controls with chronic diseases, suggesting the proteins may play a role in overall kidney disease development. Conclusions: CKAP4 was found to be differentially expressed in both AKI and CKD when compared to UHCs; hence, this biomarker could be a prognostic senescence biomarker of both AKI and CKD.https://www.mdpi.com/2073-4409/13/19/1613senescencechronic kidney diseaseacute kidney injurybiomarkermachine learning |
| spellingShingle | Sean McCallion Thomas McLarnon Eamonn Cooper Andrew R. English Steven Watterson Melody El Chemaly Cathy McGeough Amanda Eakin Tan Ahmed Philip Gardiner Adrian Pendleton Gary Wright Declan McGuigan Maurice O’Kane Aaron Peace Ying Kuan David S. Gibson Paula L. McClean Catriona Kelly Victoria McGilligan Elaine K. Murray Frank McCarroll Anthony J. Bjourson Taranjit Singh Rai Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients Cells senescence chronic kidney disease acute kidney injury biomarker machine learning |
| title | Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients |
| title_full | Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients |
| title_fullStr | Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients |
| title_full_unstemmed | Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients |
| title_short | Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients |
| title_sort | senescence biomarkers ckap4 and ptx3 stratify severe kidney disease patients |
| topic | senescence chronic kidney disease acute kidney injury biomarker machine learning |
| url | https://www.mdpi.com/2073-4409/13/19/1613 |
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