Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review
Acute hyperuricemia most commonly occurs in patients who experience tumor lysis syndrome. Hyperuricemia along with other electrolyte abnormalities like hyperkalemia, hypocalcemia, and hyperphosphatemia leads to acute kidney injury (AKI) due to acute uric acid nephropathy which is associated with sig...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2019/4890287 |
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| author | Chinmay Patel Caitlin P. Wilson Naveed Ahmed Yousef Hattab |
| author_facet | Chinmay Patel Caitlin P. Wilson Naveed Ahmed Yousef Hattab |
| author_sort | Chinmay Patel |
| collection | DOAJ |
| description | Acute hyperuricemia most commonly occurs in patients who experience tumor lysis syndrome. Hyperuricemia along with other electrolyte abnormalities like hyperkalemia, hypocalcemia, and hyperphosphatemia leads to acute kidney injury (AKI) due to acute uric acid nephropathy which is associated with significant morbidity. High risk patients are thus closely monitored for signs of these laboratory abnormalities. Extreme exercise, rhabdomyolysis, and seizures are rare causes of acute hyperuricemia. Serum uric acid level is not routinely monitored as a part of postictal labs. We report an unusual case of AKI in a young male with recurrent seizures and no associated rhabdomyolysis who was found to have acute uric acid nephropathy. Timely administration of Rasburicase prevented the need for dialysis in this patient and led to complete renal recovery. This case illustrates the importance of doing a urine microscopy and checking uric acid level in patients with recurrent seizures who develop unexplainable AKI, as timely management helps improve outcome. We also briefly review the pathophysiology of seizure related hyperuricemia and acute uric acid nephropathy. |
| format | Article |
| id | doaj-art-5f3329c81ae24d408d80f3df428f76de |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-5f3329c81ae24d408d80f3df428f76de2025-08-20T03:34:22ZengWileyCase Reports in Nephrology2090-66412090-665X2019-01-01201910.1155/2019/48902874890287Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and ReviewChinmay Patel0Caitlin P. Wilson1Naveed Ahmed2Yousef Hattab3University of Pikeville, Kentucky College of Osteopathic Medicine, Division of Nephrology, Pikeville Medical Center, USAFamily Practice Residency Program, Pikeville Medical Center, USANeurology Program, University of Pikeville, Kentucky College of Osteopathic Medicine, Pikeville Medical Center, USADivision of Pulmonary and Critical Care Medicine, Pikeville Medical Center, USAAcute hyperuricemia most commonly occurs in patients who experience tumor lysis syndrome. Hyperuricemia along with other electrolyte abnormalities like hyperkalemia, hypocalcemia, and hyperphosphatemia leads to acute kidney injury (AKI) due to acute uric acid nephropathy which is associated with significant morbidity. High risk patients are thus closely monitored for signs of these laboratory abnormalities. Extreme exercise, rhabdomyolysis, and seizures are rare causes of acute hyperuricemia. Serum uric acid level is not routinely monitored as a part of postictal labs. We report an unusual case of AKI in a young male with recurrent seizures and no associated rhabdomyolysis who was found to have acute uric acid nephropathy. Timely administration of Rasburicase prevented the need for dialysis in this patient and led to complete renal recovery. This case illustrates the importance of doing a urine microscopy and checking uric acid level in patients with recurrent seizures who develop unexplainable AKI, as timely management helps improve outcome. We also briefly review the pathophysiology of seizure related hyperuricemia and acute uric acid nephropathy.http://dx.doi.org/10.1155/2019/4890287 |
| spellingShingle | Chinmay Patel Caitlin P. Wilson Naveed Ahmed Yousef Hattab Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review Case Reports in Nephrology |
| title | Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review |
| title_full | Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review |
| title_fullStr | Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review |
| title_full_unstemmed | Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review |
| title_short | Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review |
| title_sort | acute uric acid nephropathy following epileptic seizures case report and review |
| url | http://dx.doi.org/10.1155/2019/4890287 |
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