Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes
Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. The...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2014/916361 |
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| author | Hizbullah Khan Nek Daraz Muhammad Nasim Khan Muhammad Said Nosheen Akhtar Amin Badshah Amir Sada Khan Murad Ali |
| author_facet | Hizbullah Khan Nek Daraz Muhammad Nasim Khan Muhammad Said Nosheen Akhtar Amin Badshah Amir Sada Khan Murad Ali |
| author_sort | Hizbullah Khan |
| collection | DOAJ |
| description | Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. They all have been synthesized and characterized by various spectroscopic techniques (elemental analysis, FTIR, and 1H NMR and the ligand 1,3-bis(2-methoxyphenyl) thiourea was synthesized by single crystal X-ray diffraction technique). The synthesized compounds were screened for their antibacterial activity against four strains of bacteria (Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus subtilis). The antitumor potential was evaluated in terms of activity against brine shrimp eggs and DNA interaction. The mixed ligand complexes have exhibited moderate antibacterial activity and promising antitumor potential. |
| format | Article |
| id | doaj-art-5f3136be0e4941bfa3a1d1495ed8a004 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-5f3136be0e4941bfa3a1d1495ed8a0042025-08-20T03:34:22ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2014-01-01201410.1155/2014/916361916361Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) ComplexesHizbullah Khan0Nek Daraz1Muhammad Nasim Khan2Muhammad Said3Nosheen Akhtar4Amin Badshah5Amir Sada Khan6Murad Ali7Department of Chemistry, University of Science and Technology, Bannu 28100, PakistanDepartment of Chemistry, University of Science and Technology, Bannu 28100, PakistanDepartment of Chemistry, Kohat University of Science and Technology, Kohat 26000, PakistanDepartment of Chemistry, Abdul Wali Khan University, Mardan 23200, PakistanDepartment of Chemistry, University of Science and Technology, Bannu 28100, PakistanDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, University of Science and Technology, Bannu 28100, PakistanDepartment of Chemistry, Kohat University of Science and Technology, Kohat 26000, PakistanFive heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. They all have been synthesized and characterized by various spectroscopic techniques (elemental analysis, FTIR, and 1H NMR and the ligand 1,3-bis(2-methoxyphenyl) thiourea was synthesized by single crystal X-ray diffraction technique). The synthesized compounds were screened for their antibacterial activity against four strains of bacteria (Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus subtilis). The antitumor potential was evaluated in terms of activity against brine shrimp eggs and DNA interaction. The mixed ligand complexes have exhibited moderate antibacterial activity and promising antitumor potential.http://dx.doi.org/10.1155/2014/916361 |
| spellingShingle | Hizbullah Khan Nek Daraz Muhammad Nasim Khan Muhammad Said Nosheen Akhtar Amin Badshah Amir Sada Khan Murad Ali Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes Bioinorganic Chemistry and Applications |
| title | Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes |
| title_full | Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes |
| title_fullStr | Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes |
| title_full_unstemmed | Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes |
| title_short | Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes |
| title_sort | synthesis structural characterization and evaluation of the biological properties of heteroleptic palladium ii complexes |
| url | http://dx.doi.org/10.1155/2014/916361 |
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