ALS and Frontotemporal Dysfunction: A Review
Though once believed to be a disease that was limited to the motor system, it is now apparent that amyotrophic lateral sclerosis (ALS) may be associated with cognitive changes in some patients. Changes are consistent with frontotemporal dysfunction, and may range from mild abnormalities only recogni...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/806306 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850223745676869632 |
|---|---|
| author | Eugene Y. Achi Stacy A. Rudnicki |
| author_facet | Eugene Y. Achi Stacy A. Rudnicki |
| author_sort | Eugene Y. Achi |
| collection | DOAJ |
| description | Though once believed to be a disease that was limited to the motor system, it is now apparent that amyotrophic lateral sclerosis (ALS) may be associated with cognitive changes in some patients. Changes are consistent with frontotemporal dysfunction, and may range from mild abnormalities only recognized with formal neuropsychological testing, to profound frontotemporal dementia (FTD). Executive function, behavior, and language are the most likely areas to be involved. Screening helpful in detecting abnormalities includes verbal or categorical fluency, behavioral inventories filled out by the caregiver, and evaluation for the presence of depression and pseudobulbar affect. Patients with cognitive dysfunction have shortened survival and may be less compliant with recommendations regarding use of feeding tubes and noninvasive ventilation. Evolving knowledge of genetic and pathological links between ALS and FTD has allowed us to better understand the overlapping spectrum of ALS and FTD. |
| format | Article |
| id | doaj-art-5f2fac408e364a5eafa4b16e959be5f9 |
| institution | OA Journals |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-5f2fac408e364a5eafa4b16e959be5f92025-08-20T02:05:49ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/806306806306ALS and Frontotemporal Dysfunction: A ReviewEugene Y. Achi0Stacy A. Rudnicki1Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USADepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAThough once believed to be a disease that was limited to the motor system, it is now apparent that amyotrophic lateral sclerosis (ALS) may be associated with cognitive changes in some patients. Changes are consistent with frontotemporal dysfunction, and may range from mild abnormalities only recognized with formal neuropsychological testing, to profound frontotemporal dementia (FTD). Executive function, behavior, and language are the most likely areas to be involved. Screening helpful in detecting abnormalities includes verbal or categorical fluency, behavioral inventories filled out by the caregiver, and evaluation for the presence of depression and pseudobulbar affect. Patients with cognitive dysfunction have shortened survival and may be less compliant with recommendations regarding use of feeding tubes and noninvasive ventilation. Evolving knowledge of genetic and pathological links between ALS and FTD has allowed us to better understand the overlapping spectrum of ALS and FTD.http://dx.doi.org/10.1155/2012/806306 |
| spellingShingle | Eugene Y. Achi Stacy A. Rudnicki ALS and Frontotemporal Dysfunction: A Review Neurology Research International |
| title | ALS and Frontotemporal Dysfunction: A Review |
| title_full | ALS and Frontotemporal Dysfunction: A Review |
| title_fullStr | ALS and Frontotemporal Dysfunction: A Review |
| title_full_unstemmed | ALS and Frontotemporal Dysfunction: A Review |
| title_short | ALS and Frontotemporal Dysfunction: A Review |
| title_sort | als and frontotemporal dysfunction a review |
| url | http://dx.doi.org/10.1155/2012/806306 |
| work_keys_str_mv | AT eugeneyachi alsandfrontotemporaldysfunctionareview AT stacyarudnicki alsandfrontotemporaldysfunctionareview |