Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression
Chronic kidney disease (CKD) represents a global health epidemic, with approximately one-third of affected individuals ultimately necessitating renal replacement therapy or transplantation. The kidney, characterized by its exceptionally high energy demands, exhibits significant sensitivity to altera...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2506812 |
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| author | Jinhu Chen Qiuyuan Zhou Lianjiu Su Lihua Ni |
| author_facet | Jinhu Chen Qiuyuan Zhou Lianjiu Su Lihua Ni |
| author_sort | Jinhu Chen |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) represents a global health epidemic, with approximately one-third of affected individuals ultimately necessitating renal replacement therapy or transplantation. The kidney, characterized by its exceptionally high energy demands, exhibits significant sensitivity to alterations in energy supply and mitochondrial function. In CKD, a compromised capacity for mitochondrial ATP synthesis has been documented. As research advances, the multifaceted roles of mitochondria, extending beyond their traditional functions in oxygen sensing and energy production, are increasingly acknowledged. Empirical studies have demonstrated a strong association between mitochondrial dysfunction and the pathogenesis of fibrosis and cellular apoptosis in CKD. Targeting mitochondrial dysfunction holds substantial therapeutic promise, with emerging insights into its epigenetic regulation in CKD, particularly involving non-coding RNAs and DNA methylation. This article presents a comprehensive review of contemporary research on mitochondrial dysfunction in relation to the onset and progression of CKD. It elucidates the associated molecular mechanisms across various renal cell types and proposes novel research avenues for CKD treatment. |
| format | Article |
| id | doaj-art-5f2dd91884ca4b2a8567f6f9d60a62ce |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-5f2dd91884ca4b2a8567f6f9d60a62ce2025-08-20T02:16:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2506812Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progressionJinhu Chen0Qiuyuan Zhou1Lianjiu Su2Lihua Ni3Department of Nephrology, Huanggang Central Hospital of Yangtze University, Huanggang, ChinaDepartment of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaChronic kidney disease (CKD) represents a global health epidemic, with approximately one-third of affected individuals ultimately necessitating renal replacement therapy or transplantation. The kidney, characterized by its exceptionally high energy demands, exhibits significant sensitivity to alterations in energy supply and mitochondrial function. In CKD, a compromised capacity for mitochondrial ATP synthesis has been documented. As research advances, the multifaceted roles of mitochondria, extending beyond their traditional functions in oxygen sensing and energy production, are increasingly acknowledged. Empirical studies have demonstrated a strong association between mitochondrial dysfunction and the pathogenesis of fibrosis and cellular apoptosis in CKD. Targeting mitochondrial dysfunction holds substantial therapeutic promise, with emerging insights into its epigenetic regulation in CKD, particularly involving non-coding RNAs and DNA methylation. This article presents a comprehensive review of contemporary research on mitochondrial dysfunction in relation to the onset and progression of CKD. It elucidates the associated molecular mechanisms across various renal cell types and proposes novel research avenues for CKD treatment.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2506812Chronic kidney diseasemitochondrial dysfunctioncell deathmitophagyoxidative stress |
| spellingShingle | Jinhu Chen Qiuyuan Zhou Lianjiu Su Lihua Ni Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression Renal Failure Chronic kidney disease mitochondrial dysfunction cell death mitophagy oxidative stress |
| title | Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression |
| title_full | Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression |
| title_fullStr | Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression |
| title_full_unstemmed | Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression |
| title_short | Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression |
| title_sort | mitochondrial dysfunction the hidden catalyst in chronic kidney disease progression |
| topic | Chronic kidney disease mitochondrial dysfunction cell death mitophagy oxidative stress |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2506812 |
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