A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction
Solvothermal reaction of 4,4’,4’-nitrilotribenzoic acid (H3TCA) with Ca(NO3)2·4H2O and Cd(NO3)2·4H2O successfully afforded a heterometallic compound, that is, [Cd2Ca(TCA)2(DMA)2(H2O)3]n·2n(DMA) (1, DMA = N,N’-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/5685596 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849412713043722240 |
|---|---|
| author | Jia Ma Jianer Wang Yuping He Yiwei Huang Yejun Chen |
| author_facet | Jia Ma Jianer Wang Yuping He Yiwei Huang Yejun Chen |
| author_sort | Jia Ma |
| collection | DOAJ |
| description | Solvothermal reaction of 4,4’,4’-nitrilotribenzoic acid (H3TCA) with Ca(NO3)2·4H2O and Cd(NO3)2·4H2O successfully afforded a heterometallic compound, that is, [Cd2Ca(TCA)2(DMA)2(H2O)3]n·2n(DMA) (1, DMA = N,N’-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of single crystal X-ray, and thermogravimetric analysis (TGA) together with powder X-ray diffraction (PXRD). Moreover, complex 1’s luminescent performance in solid state was also discussed at environmental temperature. The applications on the ischemic cerebral infarction therapy were evaluated, and the specific mechanism was investigated at the same time. Firstly, the hypersensitivity C-reactive protein (hs-CRP) content in human brain microvascular endothelial cell (HBMEC) was measured with real-time reverse transcription-polymerase chain reaction (RT-PCR). Then, interleukin-18 and interleukin-1β content released through the HBMEC was detected with enzyme-linked immunosorbent assay (ELISA). |
| format | Article |
| id | doaj-art-5f2cb265a3f74afc87042e4de25cd021 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-5f2cb265a3f74afc87042e4de25cd0212025-08-20T03:34:21ZengWileyJournal of Chemistry2090-90712021-01-01202110.1155/2021/5685596A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral InfarctionJia Ma0Jianer Wang1Yuping He2Yiwei Huang3Yejun Chen4Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologySolvothermal reaction of 4,4’,4’-nitrilotribenzoic acid (H3TCA) with Ca(NO3)2·4H2O and Cd(NO3)2·4H2O successfully afforded a heterometallic compound, that is, [Cd2Ca(TCA)2(DMA)2(H2O)3]n·2n(DMA) (1, DMA = N,N’-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of single crystal X-ray, and thermogravimetric analysis (TGA) together with powder X-ray diffraction (PXRD). Moreover, complex 1’s luminescent performance in solid state was also discussed at environmental temperature. The applications on the ischemic cerebral infarction therapy were evaluated, and the specific mechanism was investigated at the same time. Firstly, the hypersensitivity C-reactive protein (hs-CRP) content in human brain microvascular endothelial cell (HBMEC) was measured with real-time reverse transcription-polymerase chain reaction (RT-PCR). Then, interleukin-18 and interleukin-1β content released through the HBMEC was detected with enzyme-linked immunosorbent assay (ELISA).http://dx.doi.org/10.1155/2021/5685596 |
| spellingShingle | Jia Ma Jianer Wang Yuping He Yiwei Huang Yejun Chen A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction Journal of Chemistry |
| title | A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction |
| title_full | A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction |
| title_fullStr | A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction |
| title_full_unstemmed | A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction |
| title_short | A New (3, 6)-Connected Heterometallic Coordination Polymer: Therapeutic and Protective Effect on Ischemic Cerebral Infarction |
| title_sort | new 3 6 connected heterometallic coordination polymer therapeutic and protective effect on ischemic cerebral infarction |
| url | http://dx.doi.org/10.1155/2021/5685596 |
| work_keys_str_mv | AT jiama anew36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT jianerwang anew36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT yupinghe anew36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT yiweihuang anew36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT yejunchen anew36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT jiama new36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT jianerwang new36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT yupinghe new36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT yiweihuang new36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction AT yejunchen new36connectedheterometalliccoordinationpolymertherapeuticandprotectiveeffectonischemiccerebralinfarction |