Apigenin ameliorates CCl4-induced hepatic fibrosis by inhibiting hepatic stellate cell activation via PI3K/AKT/GSK3β pathway in mice

Apigenin ameliorates CCl4-induced hepatic fibrosis by inhibiting hepatic stellate cell activation via PI3K/AKT/GSK3β pathway in mice

Objective: To investigate the effect of apigenin on carbon tetrachloride (CCl4)-induced liver fibrosis and elucidate the underlying mechanisms. Methods: A mouse model of CCl4-induced liver fibrosis was used to evaluate the effects of apigenin. Liver function was assessed using biochemical tests, and...

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Main Authors: Tao Sun, Bao-Ying Wang, Xiao-Ying Li, Xiu-Zhi Zhang, Yan-Fei Lei, Shan-Fa Yu, Ning-Ning Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
liver fibrosis
ccl4
hepatic stellate cell
pi3k/ akt/gsk3β
apigenin
Online Access:https://journals.lww.com/10.4103/apjtb.apjtb_634_24
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