Inferring causal metabolic signals that regulate the dynamic TORC1‐dependent transcriptome

Inferring causal metabolic signals that regulate the dynamic TORC1‐dependent transcriptome

Abstract Cells react to nutritional cues in changing environments via the integrated action of signaling, transcriptional, and metabolic networks. Mechanistic insight into signaling processes is often complicated because ubiquitous feedback loops obscure causal relationships. Consequently, the endog...

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Main Authors: Ana Paula Oliveira, Sotiris Dimopoulos, Alberto Giovanni Busetto, Stefan Christen, Reinhard Dechant, Laura Falter, Morteza Haghir Chehreghani, Szymon Jozefczuk, Christina Ludwig, Florian Rudroff, Juliane Caroline Schulz, Asier González, Alexandre Soulard, Daniele Stracka, Ruedi Aebersold, Joachim M Buhmann, Michael N Hall, Matthias Peter, Uwe Sauer, Jörg Stelling
Format: Article
Language:English
Published: Springer Nature 2015-04-01
Series:Molecular Systems Biology
Subjects:
causal inference
network motifs
nutrient signaling
target of rapamycin pathway
Online Access:https://doi.org/10.15252/msb.20145475
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