RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage

RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage

Abstract Specification of primordial germ cells (PGCs) establishes germline development during early embryogenesis, yet the underlying mechanisms in humans remain largely unknown. Here, we reveal the functional roles of germline-specific RNA-binding protein (RBP) DND1 in human PGC (hPGC) specificati...

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Bibliographic Details
Main Authors: Ziqi Wang, Honglin Yu, Zhaoyu Gu, Xiaohui Shi, Jiayue Ma, Qizhe Shao, Yao Yao, Shuo Yao, Yan Xu, Yashi Gu, Jiayue Dai, Qi Liu, Jingyan Shi, Rujie Qi, Yue Jin, Yuqian Liu, Xinchen Shen, Wenwen Huang, Heng-Jia Liu, Min Jin, Wanlu Liu, Matthew Brook, Di Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57490-6
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