Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations
Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy with distinct regional variations, particularly concentrated in East Asia, including China and Japan. The Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) system offers simplicity but la...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1621862/full |
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| author | Kexun Li Kexun Li Simiao Lu Simiao Lu Jie Mao Yongtao Han Lin Peng Xuefeng Leng |
| author_facet | Kexun Li Kexun Li Simiao Lu Simiao Lu Jie Mao Yongtao Han Lin Peng Xuefeng Leng |
| author_sort | Kexun Li |
| collection | DOAJ |
| description | Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy with distinct regional variations, particularly concentrated in East Asia, including China and Japan. The Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) system offers simplicity but lacks emphasis on anatomical specificity, such as upper mediastinal metastases. Conversely, the Japan Esophageal Society (JES) system provides detailed regional stratification, aiding preoperative planning and tailored therapy, though it demands greater clinical expertise. This review evaluates the current state of pathological lymph node staging systems for ESCC, comparing the UICC/AJCC and JES approaches and exploring emerging trends in China toward station-based staging. |
| format | Article |
| id | doaj-art-5f25b80301954e57a142bb2fc73fe9ce |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-5f25b80301954e57a142bb2fc73fe9ce2025-08-20T03:09:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.16218621621862Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stationsKexun Li0Kexun Li1Simiao Lu2Simiao Lu3Jie Mao4Yongtao Han5Lin Peng6Xuefeng Leng7Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, ChinaDepartment of Thoracic Surgery I, Key Laboratory of Lung Cancer of Yunnan Province, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, ChinaSchool of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Thoracic Surgery I, Key Laboratory of Lung Cancer of Yunnan Province, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, ChinaDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, ChinaEsophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy with distinct regional variations, particularly concentrated in East Asia, including China and Japan. The Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) system offers simplicity but lacks emphasis on anatomical specificity, such as upper mediastinal metastases. Conversely, the Japan Esophageal Society (JES) system provides detailed regional stratification, aiding preoperative planning and tailored therapy, though it demands greater clinical expertise. This review evaluates the current state of pathological lymph node staging systems for ESCC, comparing the UICC/AJCC and JES approaches and exploring emerging trends in China toward station-based staging.https://www.frontiersin.org/articles/10.3389/fonc.2025.1621862/fullesophageal squamous cell carcinomapathological n-categorylymph nodeprognosisUICC/AJCCJES |
| spellingShingle | Kexun Li Kexun Li Simiao Lu Simiao Lu Jie Mao Yongtao Han Lin Peng Xuefeng Leng Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations Frontiers in Oncology esophageal squamous cell carcinoma pathological n-category lymph node prognosis UICC/AJCC JES |
| title | Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations |
| title_full | Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations |
| title_fullStr | Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations |
| title_full_unstemmed | Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations |
| title_short | Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations |
| title_sort | evolution of lymph node staging in esophageal squamous cell carcinoma insights from lymph node metastatic stations |
| topic | esophageal squamous cell carcinoma pathological n-category lymph node prognosis UICC/AJCC JES |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1621862/full |
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