More than just a number: the gut microbiota and brain function across the extremes of life
Understanding the interrelationship between the gut microbiota and host physiology, although still in its relative infancy, has taken important steps forward over the past decade. In the context of brain disorders including those characterized by neurodevelopmental and neurodegenerative changes ther...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2418988 |
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| author | Nathan D. Nuzum Clara Deady Sarah Kittel-Schneider John F. Cryan Siobhain M. O'Mahony Gerard Clarke |
| author_facet | Nathan D. Nuzum Clara Deady Sarah Kittel-Schneider John F. Cryan Siobhain M. O'Mahony Gerard Clarke |
| author_sort | Nathan D. Nuzum |
| collection | DOAJ |
| description | Understanding the interrelationship between the gut microbiota and host physiology, although still in its relative infancy, has taken important steps forward over the past decade. In the context of brain disorders including those characterized by neurodevelopmental and neurodegenerative changes there have been important advances. However, initially research involved correlational analyses, had limited translational scope, and lacked functional assessments. Thus, largescale longitudinal clinical investigations that assess causation and underlying mechanisms via in depth analysis methods are needed. In neurodegeneration research, strong causal evidence now links the gut microbiome to Alzheimer's (AD), and Parkinson's Disease (PD), as supported by human-to-animal transplantation studies. Longitudinal interventions are being conducted in AD, PD, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis. Neurodevelopmental research has also seen a boon in microbiome-related clinical research including in autism, Attention-deficit/hyperactivity disorder, and schizophrenia, which is confirming prior animal model work regarding the key time-windows in the gut microbiome important for infant cognition. While recent research advances represent important progress, fundamental knowledge gaps and obstacles remain. Knowing how and why the gut microbiome changes at the extremes of life will develop our mechanistic understanding and help build the evidence base as we strive toward counteracting microbial missteps with precision therapeutic interventions. |
| format | Article |
| id | doaj-art-5f25049156d447e48f1bd569e7c38688 |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-5f25049156d447e48f1bd569e7c386882025-02-07T07:41:06ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2418988More than just a number: the gut microbiota and brain function across the extremes of lifeNathan D. Nuzum0Clara Deady1Sarah Kittel-Schneider2John F. Cryan3Siobhain M. O'Mahony4Gerard Clarke5APC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandUnderstanding the interrelationship between the gut microbiota and host physiology, although still in its relative infancy, has taken important steps forward over the past decade. In the context of brain disorders including those characterized by neurodevelopmental and neurodegenerative changes there have been important advances. However, initially research involved correlational analyses, had limited translational scope, and lacked functional assessments. Thus, largescale longitudinal clinical investigations that assess causation and underlying mechanisms via in depth analysis methods are needed. In neurodegeneration research, strong causal evidence now links the gut microbiome to Alzheimer's (AD), and Parkinson's Disease (PD), as supported by human-to-animal transplantation studies. Longitudinal interventions are being conducted in AD, PD, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis. Neurodevelopmental research has also seen a boon in microbiome-related clinical research including in autism, Attention-deficit/hyperactivity disorder, and schizophrenia, which is confirming prior animal model work regarding the key time-windows in the gut microbiome important for infant cognition. While recent research advances represent important progress, fundamental knowledge gaps and obstacles remain. Knowing how and why the gut microbiome changes at the extremes of life will develop our mechanistic understanding and help build the evidence base as we strive toward counteracting microbial missteps with precision therapeutic interventions.https://www.tandfonline.com/doi/10.1080/19490976.2024.2418988Neurodevelopmentneurodegenerationgut bacteriagut-brain-axisearly-lifeolder adult |
| spellingShingle | Nathan D. Nuzum Clara Deady Sarah Kittel-Schneider John F. Cryan Siobhain M. O'Mahony Gerard Clarke More than just a number: the gut microbiota and brain function across the extremes of life Gut Microbes Neurodevelopment neurodegeneration gut bacteria gut-brain-axis early-life older adult |
| title | More than just a number: the gut microbiota and brain function across the extremes of life |
| title_full | More than just a number: the gut microbiota and brain function across the extremes of life |
| title_fullStr | More than just a number: the gut microbiota and brain function across the extremes of life |
| title_full_unstemmed | More than just a number: the gut microbiota and brain function across the extremes of life |
| title_short | More than just a number: the gut microbiota and brain function across the extremes of life |
| title_sort | more than just a number the gut microbiota and brain function across the extremes of life |
| topic | Neurodevelopment neurodegeneration gut bacteria gut-brain-axis early-life older adult |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2418988 |
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