ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement
Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are autoimmune diseases characterized by inflammation of small to medium blood vessels. This case explores AAV pathophysiology, its link to bronchiectasis and leucocytoclasia, ANCA positivity, and current treatmen...
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The Kandy Society of Medicine
2024-12-01
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| Series: | Sri Lanka Journal of Medicine |
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| Online Access: | https://account.sljm.sljol.info/index.php/sljo-j-sljm2/article/view/552 |
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| author | N. M. M. Risly I. K. Jayasinghe N. Athauda E. M. C. B. Ekanayake S. Hettige J. F. Sahana |
| author_facet | N. M. M. Risly I. K. Jayasinghe N. Athauda E. M. C. B. Ekanayake S. Hettige J. F. Sahana |
| author_sort | N. M. M. Risly |
| collection | DOAJ |
| description | Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are autoimmune diseases characterized by inflammation of small to medium blood vessels. This case explores AAV pathophysiology, its link to bronchiectasis and leucocytoclasia, ANCA positivity, and current treatment guidelines.
Case Presentation: A 48-year-old with abdominal pain, rash, hypertensive urgency, and respiratory symptoms was diagnosed with AAV, confirmed by skin biopsy and positive C-ANCA, stool occult blood with negative abdominal imaging along with bronchiectasis on HRCT. The patient initially failed to respond to broad-spectrum antibiotics but improved with high-dose corticosteroids.
Conclusion: We highlight an atypical presentation of AAV, showing the importance of timely immunosuppressive therapy for favorable outcomes. |
| format | Article |
| id | doaj-art-5f231cad86fa42a58daff577a37f0b7e |
| institution | OA Journals |
| issn | 2579-1990 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Kandy Society of Medicine |
| record_format | Article |
| series | Sri Lanka Journal of Medicine |
| spelling | doaj-art-5f231cad86fa42a58daff577a37f0b7e2025-08-20T01:58:27ZengThe Kandy Society of MedicineSri Lanka Journal of Medicine2579-19902024-12-01333667010.4038/sljm.v33i3.552552ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal InvolvementN. M. M. Risly0https://orcid.org/0009-0000-4743-5034I. K. Jayasinghe1N. Athauda2E. M. C. B. Ekanayake3S. Hettige4J. F. Sahana5National Hospital KandyNational Hospital KandyNational Hospital KandyNational Hospital KandyNational Hospital KandyUniversity of PeradeniyaIntroduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are autoimmune diseases characterized by inflammation of small to medium blood vessels. This case explores AAV pathophysiology, its link to bronchiectasis and leucocytoclasia, ANCA positivity, and current treatment guidelines. Case Presentation: A 48-year-old with abdominal pain, rash, hypertensive urgency, and respiratory symptoms was diagnosed with AAV, confirmed by skin biopsy and positive C-ANCA, stool occult blood with negative abdominal imaging along with bronchiectasis on HRCT. The patient initially failed to respond to broad-spectrum antibiotics but improved with high-dose corticosteroids. Conclusion: We highlight an atypical presentation of AAV, showing the importance of timely immunosuppressive therapy for favorable outcomes.https://account.sljm.sljol.info/index.php/sljo-j-sljm2/article/view/552anca associated vasculitisbronchiectasisleucocytoclastic vasculitis |
| spellingShingle | N. M. M. Risly I. K. Jayasinghe N. Athauda E. M. C. B. Ekanayake S. Hettige J. F. Sahana ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement Sri Lanka Journal of Medicine anca associated vasculitis bronchiectasis leucocytoclastic vasculitis |
| title | ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement |
| title_full | ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement |
| title_fullStr | ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement |
| title_full_unstemmed | ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement |
| title_short | ANCA-associated Leucocytoclastic Vasculitis presenting with Bronchiectasis, GI Involvement and Hypertensive Urgency: A Complex Case without Renal Involvement |
| title_sort | anca associated leucocytoclastic vasculitis presenting with bronchiectasis gi involvement and hypertensive urgency a complex case without renal involvement |
| topic | anca associated vasculitis bronchiectasis leucocytoclastic vasculitis |
| url | https://account.sljm.sljol.info/index.php/sljo-j-sljm2/article/view/552 |
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