Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD
Abstract The specific mechanism underlying the effect of changes in brain iron content on the development of RBD secondary to PD remains unclear. 27 PD patients with secondary RBD (PD-RBD+), 24 PD patients without RBD (PD-RBD-), and 32 healthy controls (HCs) were included. Paramagnetic susceptibilit...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01043-7 |
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| _version_ | 1849769179889008640 |
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| author | Lining Dong Wenyu Zhou Ran An Zheng Wang Wei Wei Hongjiang Wei Zhenchang Wang Xuan Wei |
| author_facet | Lining Dong Wenyu Zhou Ran An Zheng Wang Wei Wei Hongjiang Wei Zhenchang Wang Xuan Wei |
| author_sort | Lining Dong |
| collection | DOAJ |
| description | Abstract The specific mechanism underlying the effect of changes in brain iron content on the development of RBD secondary to PD remains unclear. 27 PD patients with secondary RBD (PD-RBD+), 24 PD patients without RBD (PD-RBD-), and 32 healthy controls (HCs) were included. Paramagnetic susceptibility was isolated using APART-QSM. The QSM and paramagnetic susceptibility (χpara) values of the whole brain and subcortical nuclei were compared among groups. The diagnostic performance was evaluated using receiver operating characteristic curve analysis. Compared with PD-RBD-, PD-RBD+ patients presented a lower χpara value in the left middle temporal gyrus. The QSM and χpara values of bilateral substantia nigra pars compacta (SNpc) were increased in both groups. The diagnostic performance of the combined index of χpara values was superior to that of the QSM value or the single index. In conclusion, paramagnetic susceptibility isolated from QSM is helpful for iron quantification and exploring the mechanism of PD-RBD+. |
| format | Article |
| id | doaj-art-5f1e2e877e81474da980125152a7d58f |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-5f1e2e877e81474da980125152a7d58f2025-08-20T03:03:32ZengNature Portfolionpj Parkinson's Disease2373-80572025-07-011111910.1038/s41531-025-01043-7Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBDLining Dong0Wenyu Zhou1Ran An2Zheng Wang3Wei Wei4Hongjiang Wei5Zhenchang Wang6Xuan Wei7Department of Radiology, Beijing Friendship Hospital, Capital Medical UniversityCollege of Engineering Science and Technology, Shanghai Ocean UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityDivision of Science and Technology, Beijing Friendship Hospital, Capital Medical UniversitySchool of Biomedical Engineering, Shanghai Jiao Tong UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Radiology, Beijing Friendship Hospital, Capital Medical UniversityAbstract The specific mechanism underlying the effect of changes in brain iron content on the development of RBD secondary to PD remains unclear. 27 PD patients with secondary RBD (PD-RBD+), 24 PD patients without RBD (PD-RBD-), and 32 healthy controls (HCs) were included. Paramagnetic susceptibility was isolated using APART-QSM. The QSM and paramagnetic susceptibility (χpara) values of the whole brain and subcortical nuclei were compared among groups. The diagnostic performance was evaluated using receiver operating characteristic curve analysis. Compared with PD-RBD-, PD-RBD+ patients presented a lower χpara value in the left middle temporal gyrus. The QSM and χpara values of bilateral substantia nigra pars compacta (SNpc) were increased in both groups. The diagnostic performance of the combined index of χpara values was superior to that of the QSM value or the single index. In conclusion, paramagnetic susceptibility isolated from QSM is helpful for iron quantification and exploring the mechanism of PD-RBD+.https://doi.org/10.1038/s41531-025-01043-7 |
| spellingShingle | Lining Dong Wenyu Zhou Ran An Zheng Wang Wei Wei Hongjiang Wei Zhenchang Wang Xuan Wei Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD npj Parkinson's Disease |
| title | Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD |
| title_full | Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD |
| title_fullStr | Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD |
| title_full_unstemmed | Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD |
| title_short | Paramagnetic susceptibility mapping better quantifies brain iron content in Parkinson’s disease with RBD |
| title_sort | paramagnetic susceptibility mapping better quantifies brain iron content in parkinson s disease with rbd |
| url | https://doi.org/10.1038/s41531-025-01043-7 |
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