The contributing role of CCR5 in dementia
Dementia is a syndrome of impaired brain function in which cognitive functions such as memory, language, attention, direction, and judgment are impaired, affecting or interfering with daily functioning. As dementia becomes more widespread, it is crucial to investigate the underlying mechanisms that...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1545302/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849320394234789888 |
|---|---|
| author | Tong Zheng Meiping Ye Meiping Ye Pingyu Zhou Pingyu Zhou |
| author_facet | Tong Zheng Meiping Ye Meiping Ye Pingyu Zhou Pingyu Zhou |
| author_sort | Tong Zheng |
| collection | DOAJ |
| description | Dementia is a syndrome of impaired brain function in which cognitive functions such as memory, language, attention, direction, and judgment are impaired, affecting or interfering with daily functioning. As dementia becomes more widespread, it is crucial to investigate the underlying mechanisms that contribute to cognitive decline. C-C chemokine receptor 5 (CCR5) has been extensively researched for its role in immune responses and function as a co-receptor in HIV infection. Current research indicates that CCR5, which acts as a regulator of synaptic plasticity, is involved in modulating various forms of learning and memory. Most studies suggest that CCR5 generally has a detrimental effect on diseases associated with dementia. This review seeks to deliver an extensive analysis of CCR5’s role in cognitive processes by summarizing existing literature from both animal and human studies. It will cover the involvement of CCR5 in standard learning and memory functions, as well as in various types of dementia. The review will specifically address conditions such as HIV-related neurocognitive impairment (HAND), Alzheimer’s disease (AD), stroke, vascular dementia, multiple sclerosis (MS), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson’s disease with dementia (PDD). Based on the fact that CCR5 plays a contributing role in many diseases that cause dementia, this review also proposed CCR5 inhibition as a possible target for alleviating and ameliorating dementia. |
| format | Article |
| id | doaj-art-5f155745ca4f4fb58bac26db430b659e |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-5f155745ca4f4fb58bac26db430b659e2025-08-20T03:50:06ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.15453021545302The contributing role of CCR5 in dementiaTong Zheng0Meiping Ye1Meiping Ye2Pingyu Zhou3Pingyu Zhou4STD Institute, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaSTD Institute, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaSTD Institute, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDementia is a syndrome of impaired brain function in which cognitive functions such as memory, language, attention, direction, and judgment are impaired, affecting or interfering with daily functioning. As dementia becomes more widespread, it is crucial to investigate the underlying mechanisms that contribute to cognitive decline. C-C chemokine receptor 5 (CCR5) has been extensively researched for its role in immune responses and function as a co-receptor in HIV infection. Current research indicates that CCR5, which acts as a regulator of synaptic plasticity, is involved in modulating various forms of learning and memory. Most studies suggest that CCR5 generally has a detrimental effect on diseases associated with dementia. This review seeks to deliver an extensive analysis of CCR5’s role in cognitive processes by summarizing existing literature from both animal and human studies. It will cover the involvement of CCR5 in standard learning and memory functions, as well as in various types of dementia. The review will specifically address conditions such as HIV-related neurocognitive impairment (HAND), Alzheimer’s disease (AD), stroke, vascular dementia, multiple sclerosis (MS), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson’s disease with dementia (PDD). Based on the fact that CCR5 plays a contributing role in many diseases that cause dementia, this review also proposed CCR5 inhibition as a possible target for alleviating and ameliorating dementia.https://www.frontiersin.org/articles/10.3389/fneur.2025.1545302/fullCCR5dementiacognitive declinelearning and memorysynaptic plasticity |
| spellingShingle | Tong Zheng Meiping Ye Meiping Ye Pingyu Zhou Pingyu Zhou The contributing role of CCR5 in dementia Frontiers in Neurology CCR5 dementia cognitive decline learning and memory synaptic plasticity |
| title | The contributing role of CCR5 in dementia |
| title_full | The contributing role of CCR5 in dementia |
| title_fullStr | The contributing role of CCR5 in dementia |
| title_full_unstemmed | The contributing role of CCR5 in dementia |
| title_short | The contributing role of CCR5 in dementia |
| title_sort | contributing role of ccr5 in dementia |
| topic | CCR5 dementia cognitive decline learning and memory synaptic plasticity |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1545302/full |
| work_keys_str_mv | AT tongzheng thecontributingroleofccr5indementia AT meipingye thecontributingroleofccr5indementia AT meipingye thecontributingroleofccr5indementia AT pingyuzhou thecontributingroleofccr5indementia AT pingyuzhou thecontributingroleofccr5indementia AT tongzheng contributingroleofccr5indementia AT meipingye contributingroleofccr5indementia AT meipingye contributingroleofccr5indementia AT pingyuzhou contributingroleofccr5indementia AT pingyuzhou contributingroleofccr5indementia |